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MetabolomicsMetabolic signatures and diagnostic models of ischemic stroke and its hypertensive subtype:a non-targeted metabolomics and machine learning
Ischemic stroke (IS) is a leading cause of death and disability worldwide, yet reliable early diagnostic biomarkers remain lacking. This study employed non-targeted metabolomics and machine learning to characterize metabolic profiles and identify diagnostic biomarkers for IS.
2026-09-17 | MTBLS15660 | MetaboLights
ProteomicsA mouse brain-based multi-omics integrative approach reveals potential blood biomarkers for ischemic stroke
Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures of acute ischemic stroke is still of primary interest for a real translational research on stroke diagnosis, prognosis and treatment. Integration of data from...
ORGANISM(S): Mus Musculus 
2020-09-07 | PXD017280 | panorama
ProteomicsHDL proteome remodeling post-stroke
Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke risk are discordant and question the value of HDL-C as a marker for stroke risk prediction. However, the relationship between other metrics of HDL, function and proteome, and stroke remain ...
ORGANISM(S): Homo Sapiens 
2021-01-24 | PXD015001 | panorama
ProteomicsA proteomics approach towards identification and validation of blood-based protein biomarkers for the differentiation of ischemic stroke from intracerebral hemorrhage
Background & aims: Stroke diagnosis is challenging in the acute phase. We aimed to determine biomarkers for the differentiation of ischemic stroke (IS) from intracerebral hemorrhage (ICH) using SWATH-MS and validate the discovered biomarkers within 24 hours using MRM proteomics. Methods: The study...
ORGANISM(S): Homo sapiens (Human) 
2022-09-21 | PXD032917 | Pride
Ischemic stroke  intracerebral hemorrhage  diagnosis  differentiation  blood  biomarkers  proteomics 
ProteomicsIdentification of potential ischemic stroke biomarkers through a brain-based multiomics integrative approach in mice
Stroke remains a major leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures of ischemic stroke within the hyper-acute phase of the disease is still of primary interest for a real translational research on stroke diagnosis, progn...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-02 | PXD016538 | Pride
Proteomics  transcriptomics  integromics  stroke  ischemic brain  mouse 
ProteomicsQuantitative analysis of rtPA-associated ICH protein serum and plasma biomarkers in acute ischemic stroke
Acute stroke, with ischemic stroke comprising 80% of all cerebrovascular incidents, has been recognized as one of the core problems in clinical medicine in need of prevention and treatment. Intravenous rtPA is the mainstay and the highest class evidence based method of acute ischemic stroke treatme...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD021713 | Pride
Plasma Serum Stroke Swath-ms 
Proteomicsproteomics characterization of the dynamics of ischemic stroke in mice
TMT-coupled proteomic analysis was conducted on mouse brain cortex tissue from five time-points up to four weeks post-stroke in the DH-MCAO mouse model. Nearly-half of the detected proteome was altered following stroke, with <10% of changes at relatively large scales. Clustering on the changed prote...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-10 | PXD025077 | Pride
Mcao Stroke biomarkers Tmt proteomics Dh-mcao Stroke Acute ischemic stroke (ais) 
ProteomicsHuman serum from patients at multiple time points after ischemic stroke
Application of acute therapies such as thrombolysis for ischemic stroke (IS) is constrained because of diagnostic uncertainty and the dynamic nature of stroke biology. To investigate changes in blood proteins after stroke and as a result of thrombolysis treatment we performed label-free quantitativ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003218 | Pride
Human Ischemic stroke Serum 
ProteomicsExploring biomarkers based on ischemic stroke proteomics studies
Exploring biomarkers based on ischemic stroke proteomics studies
ORGANISM(S): Homo Sapiens 
2022-10-27 | PXD036840 |
ProteomicsThrombus proteomics reveals new candidate biomarkers of stroke etiology
In this study, we have profiled the protein content of intravascular thrombotic material from stroke patients in the acute stage by quantitative proteomics. To this end, thrombotic material obtained by intra-arterial thrombolysis from stoke patients with different etiologies by TOAST classification ...
ORGANISM(S): Homo Sapiens (human) 
2024-05-24 | PXD042442 | JPOST Repository
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