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TranscriptomicsSMC5/6 facilitates joint molecule resolution and stepwise loss of cohesin to promote meiotic chromosome segregation
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineated, the role of the third SMC complex, Smc5/6, rema...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-27 | E-GEOD-44852 | biostudies-arrayexpress
TranscriptomicsTranscription-dependent positioning of Structural Maintenance of Chromosome complexes across the genome: RNA-Seq
The Structural Maintenance of Chromosomes (SMC) complexes regulate the chromosome structures essential for proper genome regulation and cell viability. In mammals, the coordinated actions of the SMC complexes condensin I, condensin II and cohesin regulate dynamic chromosome structures throughout th...
ORGANISM(S): Mus musculus 
2013-10-28 | E-GEOD-46316 | biostudies-arrayexpress
ProteomicsMitotic chromosome scaffold
Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC
ORGANISM(S): Gallus Gallus 
2018-10-07 | PXD007269 | JPOST Repository
Proteomicsmitotic chromosome scaffold SMC2ON vs OFF
Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC
ORGANISM(S): Gallus Gallus 
2018-10-07 | PXD008429 | JPOST Repository
ProteomicsStructural maintenance of chromosomes (SMCs) proteins are required for developmental DNA elimination in Paramecium tetraurelia
To study the role of structural maintenance of chromosome (SMC)4-1 and SMC4-2 during programmed genome rearrangement in Paramecium tetraurelia. Paramecium SMC4-1 and SMC4-2 was tagged with 3 FLAG and HA at its C-terminal separately. The recombinant plasmid was microinjected into macronuclear and use...
ORGANISM(S): Paramecium tetraurelia 
2023-12-05 | PXD041826 | Pride
Paramecium tetraurelia Dna elimination Mitosis Structural maintenance of chromosome (smc) Meiosis 
TranscriptomicsEvidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge
Cohesin is a multisubunit complex that mediates sister-chromatid cohesion. Its Smc1 and Smc3 subunits possess ABC-like ATPases at one end of 50 nm long coiled coils. At the other ends are pseudosymmetrical hinge domains that interact to create V-shaped Smc1/Smc3 heterodimers. N- and C-terminal domai...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-4827 | biostudies-arrayexpress
TranscriptomicsSpatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development
Hi-C analysis of the chromosome organization during sporulation in Streptomyces venezuelae. The experiment includes the effect of ParA, ParB, SMC, and HupS proteins on the chromosome structure.
ORGANISM(S): Streptomyces venezuelae 
2020-12-09 | E-MTAB-9810 | biostudies-arrayexpress
UnknownSOS induction in a subpopulation of structural maintenance of chromosome (Smc) mutant cells in Bacillus subtilis.
Not available
S-EPMC1913351 | biostudies-literature
TranscriptomicsConstitutive stringent response restores viability of Bacillus subtilis lacking Structural Maintenance of Chromosome protein
Bacillus subtilis mutants lacking the SMC-ScpAB complex are severely impaired for chromosome condensation and partitioning, DNA repair, and cells are not viable under standard laboratory conditions. We isolated suppressor mutations that restored the capacity of a smc deletion mutant (Δsmc) to grow u...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2015-09-23 | E-GEOD-73315 | biostudies-arrayexpress
TranscriptomicsChromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways
The SMC protein complexes safeguard genomic integrity through their functions in chromosome segregation and repair. The chromosomal localization of the budding yeast Smc5/6 complex here determined reveals that the complex works specifically on the duplicated genome in differently regulated pathways....
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4808 | biostudies-arrayexpress
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