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MetabolomicsPhenotypes and Multi—omics Reveal Changes and Molecular Mechanism of Suspension Adaptation of HEK293 Cells Structural Remodelling, Metabolic Reconstruction and Stress Resistance

Human embryonic kidney 293 (HEK293) cells have been successfully adapted from adherent to suspension culture and have been widely applied in both scientific research and the pharmaceutical industry. However, the alterations in cells during the adaptation have not been well described, which raise ...

2025-12-16 | MTBLS13517 | MetaboLights
MetabolomicsIntegrated Proteomic and Metabolomic Analyses Show Differential Effects of Glucose Availability in Marine Synechococcus and Prochlorococcus

We compared changes induced by the addition of 100 nM and 5 mM glucose on the proteome and metabolome complements in Synechococcus sp. strains WH8102, WH7803, and BL107 and Prochlorococcus sp. strains MED4, SS120, and MIT9313, grown either under standard light conditions or in d...

2023-02-06 | MTBLS5462 | MetaboLights
TranscriptomicsMaternal age effect on mouse oocytes: new biological insight from proteomic analysis
The long-standing view of 'immortal germ line versus mortal soma' poses a fundamental question in biology concerning how oocytes age in molecular terms. A mainstream hypothesis is that maternal aging of oocytes has its roots in gene transcription. Investigating the proteins resulting from mRNA trans...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-42959 | biostudies-arrayexpress
GenomicsEpigenomic, transcriptomic and proteomic characterizations of reference samples
Epigenomic, transcriptomic and proteomic characterizations of reference samples
PRJNA1117883 | ENA
UnknownStructural and Proteomic Analysis of the Mouse Cathepsin B-DARPin 4m3 Complex Reveals Species-Specific Binding Determinants.
Not available
S-EPMC12732864 | biostudies-literature
ProteomicsProteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.
Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to any perturbation or stimulus, protein structure may be altered by a variety of molecular events, such as post translational modification, protein-protein interaction, agg...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-10 | PXD031627 | Pride
Alpha-synuclein Shotgun proteomics Yeast Structural proteomics Lip-ms 
ProteomicsProteome-wide structural changes measured with 2 limited proteolysis-mass spectrometry: an advanced 3 protocol for high-throughput applications.
Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to any perturbation or stimulus, protein structure may be altered by a variety of molecular events, such as post translational modification, protein-protein interaction, agg...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-10 | PXD031616 | Pride
Shotgun proteomics Human alpha-synuclein Yeast Structural proteomics Lip-ms 
ProteomicsStructural Alternation in Heat Shock Proteins of Activated Macrophages
The inflammatory response of macrophages is an orderly and complex process under strict reg-ulation accompanied by drastic changes in morphology and functions. It is predicted that pro-teins will undergo structural changes during these finely regulated processes. However, changes in structural prote...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029672 | Pride
Structural proteomics  raw264.7  lps  lip-ms  hsp60 
UnknownA Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.
Not available
S-EPMC6097907 | biostudies-literature
TranscriptomicsTranscriptomic and Proteomic Analysis of Saccharomyces cerevisiae with Secretion of Cellobiohydrolases
The aim of present study is to understand the impact of genetic engineering event, integration of ClCBH2 gene into yeast genome, as well as the subsequent biological process, such as expression and secretion of CBH2 protein. Further, the ‘dosage’ of genetic engineering event, the copy number inserte...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-27 | E-GEOD-72413 | biostudies-arrayexpress
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