Sort   by:  
 Page size 
MetabolomicsImaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
MetabolomicsConnecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography
Our understanding of metabolic interactions between small symbiotic animals and bacteria or parasitic eukaryotes that reside within their bodies is extremely limited. This gap in knowledge originates from a methodological challenge, namely to connect histological changes in host tissues induced by b...
2021-07-06 | MTBLS2639 | MetaboLights
MetabolomicsFunctional metabolomics as a tool to analyze Mediator function and structure in plants
Mediator is a multiprotein transcriptional co-regulator complex composed of four modules; Head, Middle, Tail, and Kinase. It conveys signals from promoter-bound transcriptional regulators to RNA polymerase II and thus plays an essential role in eukaryotic gene regulation. We describe subunit localiz...
2018-01-30 | MTBLS450 | MetaboLights
TranscriptomicsSingle cell Hi-C reveals cell-to-cell variability in chromosome structure
Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture assess contacts for millions of loci simultaneously, but do so by averaging chromosome conformat...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-48262 | biostudies-arrayexpress
ProteomicsProteomic landscape of murine intervertebral disc reveals mechanisms involved in homeostasis and disc structure maintenance
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a healthy disc. Using a quantitative proteomic approach, we analyzed methodically the differences existing between IVD genders, levels and ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD006671 | Pride
Mouse intervertebral disc Nucleus pulposus Annulus fibrosus Proteomic Homeostasis Structure maintenance 
TranscriptomicsZscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells
Zinc finger and SCAN domain-containing 10 (Zscan10, also known as Zfp206) encodes a transcription factor that has been reported to be involved in the maintenance of pluripotency in mouse embryonic stem (ES) cells. Here we generated inducible knockout ES cells for Zscan10 using the Cre-loxP system an...
ORGANISM(S): Mus musculus 
2015-12-20 | E-GEOD-76143 | biostudies-arrayexpress
GenomicsClonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include the maximisation of response and use of maintenance therapy. We used whole exome sequencing to study the genetics of paired presentati...
EGAS00001003539 | EGA
TranscriptomicsControl of chromatin structure by Spt6 has different consequences in coding and regulatory regions
Spt6 is a highly conserved factor that carries out important functions in transcription and chromatin structure. To gain new insights into Spt6, we measured nucleosome occupancy along Saccharomyces cerevisiae chromosome III in an spt6 mutant and found that the level of nucleosomes is greatly reduced...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-01 | E-GEOD-21787 | biostudies-arrayexpress
GenomicsETO Family Protein Mtgr1 Mediates Prdm14 Functions in Stem Cell Maintenance
Prdm14 is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation. It exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation. Here, we show that this rep...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-74547 | biostudies-arrayexpress
GenomicsDynamic alterations of 3D chromatin structure during differentiation
Regulation of gene expression underlies the establishment and maintenance of cell identity. Chromatin structure and gene activity are linked at long-range via positioning of loci to transcriptionally permissive (euchromatin) or repressive (heterochromatin) environments and at short-range by connecti...
ORGANISM(S): Mus musculus 
2019-08-27 | E-MTAB-2063 | biostudies-arrayexpress
Sort   by:  
 Page size