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ProteomicsDetection of structure-specific interactions of Rab GTPases
Protein–protein interactions (PPIs) mediate multiple essential functions and regulatory events in living organisms. The physical interactome of a given protein can be abnormally altered in response to external and internal cues, thus modulating cell physiology and contributing to human pathologies i...
ORGANISM(S): Homo sapiens (Human) 
2024-02-10 | PXD048849 | Pride
Lc-msms Interactome Mass spectrometry Limited proteolysis Structural proteomics Protein-protein interactions Proteomics Rab gtpases Structure-specific interactions 
MetabolomicsIntegrating metagenome-scale metabolic models and metabolomics to explore candidate biochemical interactions in cultivated Microcystis phycospheres

Favoured by global changes, freshwater cyanobacterial harmful blooms generate major ecological, economical and public health challenges. Microcystis, one of the most widespread cyanobacterial genera, grows within a phycosphere where specialised interactions with its microbiome occur, and...

2026-08-14 | MTBLS13909 | MetaboLights
ProteomicsDetection of structure-specific protein–protein interactions of alpha-synuclein
Parkinson’s disease (PD) is a neurodegenerative disorder associated with the accumulation of intraneuronal protein aggregates called Lewy bodies. These inclusions contain aberrantly folded and aggregated alpha-synuclein (aSyn), a key protein involved in the pathology of PD, for which the mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-10 | PXD039784 | Pride
Amyloid fibrils Neurodegeneration Structural proteomics Protein-protein interactions Lc-msms Alpha-synuclein Interactome Induced pluripotent stem cell-derived cortical neurons Mass spectrometry Limited proteolysis Parkinson’s disease Proteomics Structure-specific interactions 
TranscriptomicsThe insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome: expression
Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in ...
ORGANISM(S): Drosophila melanogaster 
2011-01-24 | E-GEOD-20312 | biostudies-arrayexpress
TranscriptomicsThe insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome: DamID
Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in ...
ORGANISM(S): Drosophila melanogaster 
2011-01-24 | E-GEOD-20311 | biostudies-arrayexpress
ProteomicsProbing antigen–antibody interactions using limited proteolysis–mass spectrometry
Protein–protein interactions (PPIs) mediate multiple essential functions and regulatory events in living organisms. The physical interactome of a given protein can be abnormally altered in response to external and internal cues, thus modulating cell physiology and contributing to human pathologies i...
ORGANISM(S): Homo sapiens (Human) 
2024-02-10 | PXD039481 | Pride
Lc-msms Antibody-antigen interaction Interactome Mass spectrometry Respiratory syncytial virus fusion glycoprotein Limited proteolysis Structural proteomics Protein-protein interactions Mammalian cells Proteomics 
TranscriptomicsMitochondrial-nuclear DNA interactions contribute to the regulation of nuclear transcript levels as part of the inter-organelle communication system
Nuclear and mitochondrial organelles must maintain a communication system. Loci on the mitochondrial genome were recently reported to interact with nuclear loci. To determine whether this is part of a DNA based communication system we used genome conformation capture to map the global network of DNA...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-17 | E-GEOD-34132 | biostudies-arrayexpress
UnknownSystematic identification of structure-specific protein-protein interactions.
Not available
S-EPMC11148107 | biostudies-literature
UnknownSystematic identification of structure-specific protein-protein interactions
Not available
S-SCDT-10_1038-S44320-024-00037-6 | biostudies-other
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
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