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TranscriptomicsFoam cell specific LXRM-NM-1 ligand
OBJECTIVE: The liver X receptor M-NM-1 (LXRM-NM-1) is a ligand-dependent nuclear receptor and the major regulator of reverse cholesterol transport in macrophages. This makes it an interesting target for mechanistic study and treatment of atherosclerosis. METHODS AND RESULTS: We optimized a promising...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-39079 | biostudies-arrayexpress
ProteomicsSyntaxin 4 (STX4) protects islet -cells from cytokine-induced senescence
Syntaxin 4 (STX4) is a plasma membrane SNARE protein known to facilitate insulin granule exocytosis in pancreatic β-cells. Recent studies have uncovered that STX4 also exerts protective effects against inflammatory and metabolic stress by stabilizing mitochondrial function and suppressing NF-κB acti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-25 | PXD069706 | Pride
Sasp Inflammation Stx4 Type 1 diabetes Beta cell senescence 
GenomicsSTX4 Over-Expression in Human islets
STX4 Over-Expression in Human islets
PRJNA492907 | ENA
TranscriptomicsSTX4 Over-Expression in Human islets
We have used RNA-seq to identify transcripts expressed in human islets harboring beta cells transduced to overexpress STX4 and induce chemokine ligand by adenoviral transduction
ORGANISM(S): Homo sapiens 
2019-03-01 | GSE120378 | GEO
GenomicsAssessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue
Assessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue
PRJNA1045675 | ENA
UnknownSTX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.
Not available
S-EPMC12602274 | biostudies-literature
UnknownStx4 is required to regulate cardiomyocyte Ca2+ handling during vertebrate cardiac development.
Not available
S-EPMC9114686 | biostudies-literature
UnknownEnrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.
Not available
S-EPMC8776765 | biostudies-literature
TranscriptomicsAssessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue
In this study, we investigate the effects of Syntax 4 (STX4) knockdown in brown adipocytes and its role in age-related changes in brown adipose tissue (BAT). Our focus was to understand the mechanisms preceding the significant loss of BAT mass observed with aging. By comparing transcriptomic profile...
ORGANISM(S): Mus musculus 
2024-02-24 | GSE248733 | GEO
UnknownSTX4 as a potential biomarker for predicting prognosis and guiding clinical treatment decisions in clear cell renal cell carcinoma.
Not available
S-EPMC10788513 | biostudies-literature
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