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TranscriptomicsPost-fasting olfactory, transcriptional, and feeding responses in Drosophila
The sensation of hunger after a period of fasting and the sensation of satiety after eating is crucial to behavioral regulation of food intake, but the biological mechanisms regulating these sensations are incompletely understood. We studied the behavioral and physiological adaptation to fasting in ...
ORGANISM(S): Drosophila melanogaster 
2011-09-23 | E-GEOD-27927 | biostudies-arrayexpress
TranscriptomicsDominant Th1 and Minimal Th17 Skewing in Discoid Lupus Revealed by Transcriptomic Comparison with Psoriasis
Discoid lupus erythematosus (DLE) is the most common skin manifestation of lupus. Despite its high frequency in systemic lupus in addition to cases without extracutaneous manifestations, targeted treatments for DLE are lacking, likely because of a dearth of knowledge of the molecular landscape of DL...
ORGANISM(S): Homo sapiens 
2013-11-18 | E-GEOD-52471 | biostudies-arrayexpress
TranscriptomicsTranscriptome of inflammatory myeloid DCs in psoriasis
Background: Previous work has identified CD11c+CD1c- dendritic cells (DCs) as the major 'inflammatory' dermal DC population in psoriasis vulgaris and CD1c+ DCs as the 'resident' cutaneous DC population. Objective: To further define molecular differences between these two myeloid dermal DC populatio...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20264 | biostudies-arrayexpress
TranscriptomicsExtensive alopecia areata is reversed by IL-23 cytokine antagonism
Alopecia areata (AA) is a prevalent disease associated with major emotional distress, and lacks effective, safe therapeutics for patients with extensive hair loss. This is the first report of hair regrowth with specific cytokine antagonism, in three patients with extensive hair loss ranging from 40%...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-74761 | biostudies-arrayexpress
TranscriptomicsCombined Use of Laser Capture Microdissection and Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions
In this study, we sought to establish the usefulness of LCM on cDNA microarray analysis. We reported that LCM samples improved the sensitivity of detection of differentially expressed genes over conventional bulk tissue analysis. We also provided the new information of chemokine and its receptor int...
ORGANISM(S): Homo sapiens 
2012-01-30 | E-GEOD-26866 | biostudies-arrayexpress
TranscriptomicsExpression data from skin biopsy samples from patients with moderate-to-severe psoriasis
A gene expression profiling sub-study was conducted in which skin biopsy samples were collected from 85 patients with moderate-to-severe psoriasis who were participating in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial. This analysis identified 4,175 probe-sets as being significantl...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-30999 | biostudies-arrayexpress
UnknownHarshlight: a "corrective make-up" program for microarray chips.
Not available
S-EPMC1327692 | biostudies-literature
UnknownComparing independent microarray studies: the case of human embryonic stem cells.
Not available
S-EPMC1183205 | biostudies-literature
TranscriptomicsTranscription profiling by array of acute and chronic atopic dermatitis compared to normal skin
Atopic dermatitis (AD) is a common disease, with an increasing prevalence. The primary pathogenesis of the disease is still elusive, resulting in lack of specific treatments. The prevailing view is that AD is a biphasic, T-cell polarized disease, with Th2 predominating acute AD, and a switch to Th1 ...
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-36842 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human response to etanercept treatment in patients with Psoriasis
The success of TNF inhibitors for treatment of psoriasis and other inflammatory diseases was previously attributed to blockade of innate immunity. In a clinical trial using etanercept TNF blocking agent to treat psoriasis vulgaris, we used affymetrix gene arrays to analyze broad gene profiles in le...
ORGANISM(S): Homo sapiens 
2009-11-09 | E-GEOD-11903 | biostudies-arrayexpress
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