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Cdc42 is a small GTPase protein whose role in polarity is widely studied. However, in vertebrates there exist 2 isoforms arising due to alternative splicing. The function and localization of these have not been studied with respect to cell polarity and cell migration. We therefore perform a mass spe...
ORGANISM(S): Homo sapiens (Human) 
2024-01-23 | PXD017477 | Pride
Prediction of protein localization plays an important role in understanding protein function and mechanism. A deep learning-based localization prediction tool (“MULocDeep”) assessing each amino acid’s contribution to the localization process provides insights into the mechanism of protein sorting an...
ORGANISM(S): Solanum tuberosum (Potato) Arabidopsis thaliana (Mouse-ear cress) Vicia faba var. faba 
2022-02-15 | PXD019987 | Pride
Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the sub-cellular localization patterns of Piwi proteins. We find that distinct piRNA pathways with differing components function in ovarian germ and somatic cells. Keywords: Epigenetics 20 li...
ORGANISM(S): Drosophila melanogaster 
RNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulation functions for rapid adjustment to changing extra- or intracellular conditions. The association of RNA-binding proteins with their targets is regulated through changing sub-cellular distribution, post-tr...
ORGANISM(S): Homo sapiens 
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