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ProteomicsHydroxyapatite-binding plasma proteins in Age-related macular degenaration
This project identifies and quantitates Hydroxyapatite binding proteins (HAP) in plasma genotyped for complement factor H (CFH) polymorphism in late stage age-related macular degeneration (AMD) patients by sequential window acquisition of all theoretical mass spectra (SWATH). This study provides ins...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD007944 | Pride
Sub-retinal pigment epithelial deposits Human plasma Amd Hydroxyapatite-binding 
UnknownImaging hydroxyapatite in sub-retinal pigment epithelial deposits by fluorescence lifetime imaging microscopy with tetracycline staining.
Not available
S-EPMC7171513 | biostudies-literature
UnknownC3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway.
Not available
S-EPMC6018664 | biostudies-literature
UnknownEnhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis).
Not available
S-EPMC5598790 | biostudies-literature
UnknownChorioretinal thickness and retinal pigment epithelial degeneration of fellow eyes in patients with unilateral neovascular age-related macular degeneration with subretinal drusenoid deposits.
Not available
S-EPMC9284825 | biostudies-literature
ProteomicsComplement factor B is critical for sub-RPE deposit formation in the Efemp1 R345W mutant mouse model with features of age-related macular degeneration
This dataset represent supplemental data for publication submitted to Human Molecular Genetics in 2022. Briefly, Efemp1 R345W is a protein misfolding-prone mutation in humans causing Doyne honeycomb retinal dystrophy/Mallatia Leventinese (DHRD/ML), a disease sharing similar clinical pathology with ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035772 | Pride
Tmt proteomics Mouse efemp1 model Age-related macular degeneration 
TranscriptomicsNon-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants
Complement Factor H (CFH) common genetic variants have been associated with age-related macular degeneration (AMD). While most previous in vitro RPE studies focused on the common p.His402Tyr CFH variant, we characterized rare CFH variants that are highly penetrant for AMD using induced pluripotent s...
ORGANISM(S): Homo sapiens 
2024-12-02 | GSE275494 | GEO
UnknownIdentification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye.
Not available
S-EPMC4321314 | biostudies-literature
UnknownComplement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice.
Not available
S-EPMC8128922 | biostudies-literature
UnknownComplement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration.
Not available
S-EPMC9840207 | biostudies-literature
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