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TranscriptomicsExpression data from human hepatic stellate cell line LX2 treated with suberoylanilide hydroxamic acid (SAHA) or valproic acid (VPA)
Suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) are both histone deacetylases inhibitor (HDACi), and are able to attenuate the activation of hepatic stelllate cells. To explore the underlying molecular mechanisms, we performed gene expression profile analyses of human hepatic stellate...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-MTAB-3764 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer brain metastases in a mouse xenograft model with vehicle of vorinostat treatment
Gene Expression Profiling of a Mouse Xenograft Model of â??Triple-Negativeâ?? Breast Cancer Brain Metastases With and Without Vorinostat Treatment. Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few...
ORGANISM(S): Homo sapiens 
2009-10-27 | E-GEOD-18544 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data from human hepatic stellate cell line LX2 treated with suberoylanilide hydroxamic acid (SAHA) or valproic acid (VPA)
Suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA ) are both histone deacetylases inhibitor (HDACi), and are able to attenuate the activation of hepatic stelllate cells. To explore the underlying molecular mechanisms, we performed miRNA expression profile analyses of human hepatic stella...
ORGANISM(S): Homo sapiens 
2019-07-20 | E-MTAB-6752 | biostudies-arrayexpress
ProteomicsAn integrated systems biology approach reveals positive and negative effects of suberoylanilide hydroxamic acid (SAHA) on HIV reactivation from latency
Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a “shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA "shock" , treatment with SAHA did not result in the reduction of reservoir size "kill". We theref...
ORGANISM(S): Homo sapiens (Human) 
2015-09-10 | PXD002150 | Pride
Human Hiv latency Cd4 t-cells Saha Suberoylanilide hydroxamic acid 
TranscriptomicsAcquired resistance of Jurkat cells to TNF-related apoptosis-inducing ligand (TRAIL): a role for histone deacetylase inhibitors as powerful apoptosis sensitizer.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be a potent inducer of apoptosis in various cancer cell lines and primary cancer cells. However, in clinical trials administration of recombinant TRAIL or TRAIL death receptor agonists did not show sufficient efficacy ...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-38745 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human liver cancer cell line HepG2 treated with doxorubicin alone or in combination with valproic acid or suberoylanilide hydroxamic acid against untreated controls
RNA sequencing was performed to characterize transcriptomic changes in the human hepatocellular carcinoma cell line HepG2 following treatment with doxorubicin (DOX), either alone or in combination with the histone deacetylase inhibitors valproic acid (VPA) or suberoylanilide hydroxamic acid (SAHA), ...
ORGANISM(S): Homo sapiens 
2026-03-24 | E-MTAB-16713 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human gastric cancer cells treated with suberoylanilide hydroxamic acid (SAHA)
Gastric cancer cell line AGS was treated with suberoylanilide hydroxamic acid (SAHA) for 24 hours. Microarray analysis was done to explore the differentially expressed genes betweenSAHA treated and control cells.
ORGANISM(S): Homo sapiens 
2011-05-01 | E-MEXP-2695 | biostudies-arrayexpress
UnknownHistone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
Not available
S-EPMC3799888 | biostudies-literature
TranscriptomicsU937 miR-194-5p (UmiR-194-5p) vs U937 miR-194-5p (UmiR-194-5p) treated with SAHA (Vorinostat; suberoylanilide hydroxamic acid)
Transcriptional profiling of U937 miR-194-5p (UmiR-194-5p) vs U937 miR-194-5p (UmiR-194-5p) treated with SAHA (Vorinostat; suberoylanilide hydroxamic acid) for 24 h at 5uM concetration
ORGANISM(S): Homo sapiens 
2017-05-22 | GSE73648 | GEO
TranscriptomicsHistone deacetylase inhibitors antagonize distinct pathways to suppress tumorigenesis of embryonal rhabdomyosarcoma.
Embryonal rhabdomyosarcoma (ERMS) is the most common soft tissue cancer in children and is characterized by myogenic differentiation arrest. The prognosis of patients with relapsed or metastatic disease remains poor. ERMS genomes show few recurrent mutations, suggesting that other molecular mechani...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-74970 | biostudies-arrayexpress
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