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MetabolomicsLipidomic analysis of CD4+ T-cell subsets (Th1,Th2,Th17 and iTreg cells) (part I)
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ORGANISM(S): Homo sapiens 
ST001676 | MetabolomicsWorkbench
ProteomicsProject Title: Proteome analysis of CD4+ T cell subsets
Functionally distinct CD4+ helper T (Th) cell subsets, such as Th1, Th2, Th17, and regulatory T cells (Treg), play a pivotal role in the host-defense against pathogen invasion and the pathogenesis of inflammatory disorders. In this project, DIA-MS-based proteome analysis was performed on naïve CD4+ ...
ORGANISM(S): Mus Musculus (mouse) 
2023-01-04 | PXD036065 | JPOST Repository
TranscriptomicsComparison of gene expression profiles between human and mouse monocyte subsets [human data]
Human and mouse blood each contain two monocyte subsets. Here, we investigated the extent of their similarity using a microarray approach. Approximately 300 genes in human and 550 genes in mouse were differentially expressed between subsets. More than 130 of these gene expression differences were co...
ORGANISM(S): Homo sapiens 
2009-12-07 | E-GEOD-18565 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles between human and mouse monocyte subsets [mouse data]
Human and mouse blood each contain two monocyte subsets. Here, we investigated the extent of their similarity using a microarray approach. Approximately 300 genes in human and 550 genes in mouse were differentially expressed between subsets. More than 130 of these gene expression differences were co...
ORGANISM(S): Mus musculus 
2009-12-03 | E-GEOD-17256 | biostudies-arrayexpress
TranscriptomicsExpression of miRNAs in human ex-vivo CD8+ T cell subsets
The aim was to assess miRNA expression in 3 human ex-vivo CD8+ T cell subsets which span from antigen inexperienced cells (NaM-CM-/ve) to early memory cells (central memory, Tcm) and later stage memory cells (effector memory, Tem) CD8+ T cells were sorted on a FACS Aria II machine. N = naM-CM-/ve ...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-54867 | biostudies-arrayexpress
TranscriptomicsExpression data of human tonsilar CD4 positive T cell subsets
Type 1 regulatory T (Tr1) cells are one of the regulatory T cell subsets that are characterized by the production of high amount of IL-10 and lack of FOXP3 expression. Lymphocyte-activation gene 3 (LAG3) is a CD4 homologue molecule and we have previously reported that LAG3 is expressed on IL-10 prod...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-73927 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human CD8+ CD161hi and CD161lo memory and naïve T cell subsets
Gene expression profiling of human CD8+ CD161hi and CD161lo central and effector memory and naïve T cell subsets. The mechanisms by which IL-17 secreting cells are regulated have not been completely elucidated. We previously identified a population of rhodamine-effluxing memory CD8+ T cells with hi...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-23663 | biostudies-arrayexpress
GenomicsMethylome of CD4+ T cell subsets
We compared the methylated and non-methylated regions in the genome of ex vivo-isolated naive CD4+ T cells, Th1 cells, Th17 cells and regulatory T cells by methyl-CpG binding domain protein sequencing (MBD-seq). Naive T cells and Th1 cells share more methylated regions than naive T cells and Th17 ce...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-45911 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of phenotypically defined human B cell subsets
Separation of B cells has been historically important in discovering their functional relevance, particularly in relation to infection, immune disorders and vaccination. Traditional use of phenotypic markers often poses problems in distinguishing heterogeneous populations such as the Double Negative...
ORGANISM(S): Homo sapiens 
2021-03-19 | E-MTAB-9544 | biostudies-arrayexpress
TranscriptomicsHIV-specific B cells are enriched within abnormal memory subsets in infected individuals
Recently, several neutralizing anti-HIV antibodies have been isolated from memory B cells of HIV-infected individuals. However, despite extensive evidence of B-cell dysfunction in HIV disease, little is known about the cells from which these rare HIV-specific antibodies originate. Accordingly, HIV e...
ORGANISM(S): Homo sapiens 
2014-06-24 | E-GEOD-56499 | biostudies-arrayexpress
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