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MetabolomicsCoupled nitrogen fixation and substrate stabilization drive ecological strategy shifts during microbial succession

Background:

Primary succession is predicted to proceed through shifts from stress-tolerant to competitive to cooperative ecological strategies as resource availability increases, yet molecular evidence for these transitions in microbial systems remains limited. Here, we used an integrated m...

2026-03-12 | MTBLS14041 | MetaboLights
ProteomicsMapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA
Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase that regulates a plethora of cellular processes. PP2A operates as a holoenzyme complex, comprising one each of the scaffolding (A), regulatory (B) and catalytic (C) subunits. PPP2CA is the principal catalytic subunit of the PP2A holoe...
ORGANISM(S): Homo sapiens (Human) 
2024-03-18 | PXD045779 | Pride
Targeted protein degradation Ppp2ca Phosphatase Dtag Phospho-proteomics Phosphorylation Pp2a Kinase Protac Substrate landscape 
TranscriptomicsTranscription profiling of Arabidosis Ler and Cvi ecotypes and 17 derived inbred recombinant lines subjected to micro-landscape fragmentation and two levels of disturbance revealing functional landscape genomics reveals genetic changes in fixed and migrating experimental populations.
We carried out a five-generation selection experiment in which two Arabidopsis accessions (Ler and Cvi) and 17 Recombinant Inbred Lines (RILs) derived from them were subjected in 24 replicated populations to four levels of micro-landscape fragmentation and two levels of disturbance, factorially cros...
ORGANISM(S): Arabidopsis thaliana 
2010-05-12 | E-MTAB-107 | biostudies-arrayexpress
UnknownComputational remodeling of an enzyme conformational landscape for altered substrate selectivity.
Not available
S-EPMC10539519 | biostudies-literature
UnknownKey mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias.
Not available
S-EPMC3757202 | biostudies-literature
TranscriptomicsIsoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq
To fully understand cell type identity and function in the nervous system there is a need to understand neuronal gene expression at the level of isoform diversity. Here we applied Next Generation Sequencing of the transcriptome (RNA-Seq) to purified sensory neurons and cerebellar granular neurons (C...
ORGANISM(S): Mus musculus 
2012-01-17 | E-GEOD-33343 | biostudies-arrayexpress
TranscriptomicsThe substrate stiffness regulates the recurrent GBM cell morphology and aggressiveness
Treating recurrent GBM is a clinical challenge due to its highly resistant and aggressive nature. In order to develop new therapeutic targets for recurrent GBM a better understanding of its molecular landscape is necessary. Here we used a cellular model, developed in our lab which generates paired p...
ORGANISM(S): Homo sapiens 
2023-06-29 | E-MTAB-11293 | biostudies-arrayexpress
GenomicsThe substrate stiffness regulates the recurrent GBM cell morphology and aggressiveness
The substrate stiffness regulates the recurrent GBM cell morphology and aggressiveness
PRJEB49973 | ENA
GenomicsThe NF-kB genomic landscape in lymphoblastoid B-cells
The nuclear factor kB (NF-kB) subunits RelA, RelB, c-Rel, p50 and p52 are each critical for B-cell development and function. To systematically characterize their responses to canonical and non-canonical NF-kB pathways activity, we performed ChIP-seq analysis in lymphoblastoid B-cells. We found a su...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-55105 | biostudies-arrayexpress
UnknownLandscape context and substrate characteristics shape fungal communities of dead spruce in urban and semi-natural forests.
Not available
S-EPMC9543266 | biostudies-literature
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