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ProteomicsCardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins
Evidence that lysosomes are important in cardiac physiology and pathology is now emerging. We describe a label-free method suitable for small cardiac tissue biopsies based on a density-separated fractionation protocol, which allows us to study endo-lysosomal (EL) proteins in guinea pig atria. The t...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-09-09 | PXD021277 | Pride
Cardiac Rab proteins Lysosome Guinea-pig Lysosome storage disease Atria 
TranscriptomicsTranslational regulation of Anopheles gambiae mRNAs in the midgut during Plasmodium falciparum infection
Malaria is caused by Plasmodium parasites, which are transmitted via the bites of infected Anopheline mosquitoes. Midgut invasion is a major bottleneck for Plasmodium development inside the mosquito vectors as a rapidly responding immune system recognizes ookinetes and recruits killing factors from ...
ORGANISM(S): Anopheles gambiae 
2012-09-21 | E-GEOD-38707 | biostudies-arrayexpress
GenomicsRumen MAGs assemblied from 5% fraction of sucrose density gradient
Towards the enrichment and functional and phylogenetic characterization of low abundant bacteria in cattle´s rumen using fractionation of ruminal fluid
PRJEB47520 | ENA
TranscriptomicsTranslational activation of developmental mRNAs during neonatal mouse testis development
The sequence of gene regulatory events that drive neonatal germ cell development in the mammalian testis is not yet clear. We assessed changes in mRNA utilization in the neonatal testis at 1 and 4 dpp, times when the testis contains quiescent gonocytes (1 dpp) and proliferating spermatogonia (4 dpp)...
ORGANISM(S): Mus musculus 
2013-07-27 | E-GEOD-49283 | biostudies-arrayexpress
UnknownDisentangling the Complexity of the Rumen Microbial Diversity Through Fractionation Using a Sucrose Density Gradient.
Not available
S-EPMC8297521 | biostudies-literature
ProteomicsProteomic Characterization of Post-Mortem Human Brain Tissue Following Ultracentrifugation-based Subcellular Fractionation
Proteomic characterization of human brain tissue is increasingly utilized to identify potential novel biomarker and drug targets for a variety of neurological diseases. In whole tissue studies, results may be driven by changes in the proportion of the largest and most abundant organelles or tissue c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-06 | PXD027456 | Pride
Subcellular fractionation Human brain Label free quantitation Alzheimer's disease 
UnknownProtocol for endolysosomal proteomics in goat atrial tissue using a refined density-gradient approach.
Not available
S-EPMC12741452 | biostudies-literature
TranscriptomicsMNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL
The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and ...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-61691 | biostudies-arrayexpress
UnknownA modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue.
Not available
S-EPMC8384914 | biostudies-literature
TranscriptomicsTime resolved ribosome profiling study of oxygen and glucose deprivation of rat pheochromocytoma cells
Oxygen and glucose metabolism plays a pivotal role in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) occurs during ischemia and stroke, resulting in extensive tissue injury and cell death. We applied time-resolved ribosome profiling technique to assess earl...
ORGANISM(S): Rattus norvegicus 
2015-04-10 | E-GEOD-60752 | biostudies-arrayexpress
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