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ProteomicsIdentification of the MuRF1 skeletal muscle ubiquitylome through quantitative proteomics
MuRF1 is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker of muscle atrophy. In this study, we used in vivo electroporation ...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-07 | PXD023872 | Pride
Ubiquitin proteomics Muscle atrophy Murf1 Protein degradation Electroporation 
TranscriptomicsSelective inhibition of Homo sapiens M1 macrophages where SP140 mRNA is inhibited using siRNA
As part of our study in understanding the role of SP140 in inflammatory pathways in macrophages, we inhibited SP140 mRNA using siRNA. Peripheral blood mononuclear cells (PBMCs) were obtained from whole blood of healthy donors (from Sanquin Institute Amsterdam or from GSK Stevenage Blood Donation U...
ORGANISM(S): Homo sapiens 
2022-07-22 | E-MTAB-12011 | biostudies-arrayexpress
UnknownCost-effective way to reduce stimulant-abuse among gay/bisexual men and transgender women: a randomized clinical trial with a cost comparison.
Not available
S-EPMC5745270 | biostudies-literature
UnknownVismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Not available
S-EPMC4534527 | biostudies-literature
TranscriptomicsTranscription profiling by tiling array of yeast ssu72, rrp6, and rco1 mutants
Genome-wide analysis of ssu72 and rrp6 mutants in Yeast
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-03 | E-TABM-936 | biostudies-arrayexpress
UnknownCorrelates of SARS-CoV-2 anti-RBD IgG antibody titers among persons experiencing homelessness in Los Angeles.
Not available
S-EPMC10210586 | biostudies-literature
UnknownBreast tumors educate the proteome of stromal tissue in an individualized but coordinated manner.
Not available
S-EPMC5712229 | biostudies-literature
TranscriptomicsMicroRNA expression during cell cycle arrest
The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or down-regulated in many types of cancers. Here we report the reciprocal relationship - that of the cell cycle controlling the miR-16 family...
ORGANISM(S): Mus musculus 
2011-09-15 | E-GEOD-31225 | biostudies-arrayexpress
UnknownTransplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.
Not available
S-EPMC10727970 | biostudies-literature
TranscriptomicsTranscription profiling of neurosphere-derived cell lines from patients with brain disorders
Understanding the molecular bases of neurological and psychiatric conditions is hampered by a lack of suitable patient-derived cellular models. The olfactory mucosa is a continually regenerating neural tissue that contains multipotent neural stem cells which are accessible and expandable in vitro as...
ORGANISM(S): Homo sapiens 
2010-06-04 | E-TABM-724 | biostudies-arrayexpress
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