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MetabolomicsLipidomic analysis of Drosophila on different sugar feeding regimes +/- trametinib

Consumption of sugar-rich diets adversely affects health and reduces life expectancy through the excessive production and storage of triacylglycerides (TAGs) leading to metabolic dysfunction. Here, using Drosophila melanogaster, we identify the conserved Ras/MAPK signalling pathway as a key media...

2026-09-02 | MTBLS14468 | MetaboLights
MetabolomicsTowards engineering ectomycorrhization into switchgrass bioenergy crops via a lectin receptor-like kinase
Soil-borne microbes can establish compatible relationships with host plants, providing a large variety of nutritive and protective compounds in exchange for photosynthesized sugars. However, the molecular mechanisms mediating the establishment of these beneficial relationships remain unclear. Our pr...
2021-08-11 | MTBLS2597 | MetaboLights
TranscriptomicsExpression profile of the fat body from bigmax mutant and wildtype third instar Drosophila melanogaster larvae
To identify genes differentially expressed in the fatbody of Drosphila melanogaster bigmax mutants, a loss-of-function allele was generated by P-element mobilization. Mutant and wildtype first instar larvae were raised on two different sources of food, control and high-sugar media. When the animals ...
ORGANISM(S): Drosophila melanogaster 
2013-02-27 | E-MTAB-699 | biostudies-arrayexpress
MetabolomicsAnalysis of the effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Liver Metabolism In Vivo
Not available
ORGANISM(S): Mus musculus 
ST000894 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of Arabidopsis dark grown seedlings response to 6h-long treatment with 90 mM sucrose
Dark grown Arabidopsis seedlings (Columbia gl1) were grown in the dark at 23°C for 4 days before adding 90 mM sucrose for 6h. Experiment Overall Design: Arabidopsis thaliana ecotype Columbia glabra (gl1-1) was used in this study. Seeds were sterilized with diluted bleach (10 min incubation in 1.7%...
ORGANISM(S): Arabidopsis thaliana 
2008-06-12 | E-GEOD-3704 | biostudies-arrayexpress
MetabolomicsTranscriptomic and metabolomic changes in postharvest sugarbeet roots reveal widespread metabolic changes in storage and identify genes potentially responsible for respiratory sucrose loss
Endogenous metabolism is primarily responsible for losses in sucrose content and processing quality in postharvest sugarbeet roots. The genes responsible for this metabolism and the transcriptional changes that regulate it, however, are largely unknown. To identify genes and metabolic pathways that ...
2024-05-15 | MTBLS1106 | MetaboLights
MetabolomicsAnalysis of the effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Serum Metabolism In Vivo using Non-Targeted Metabolomics Analysis
Not available
ORGANISM(S): Mus musculus 
ST000895 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of liver from wild type vs glycerol kinase knockout mice to understand the molecular pathogenesis of GKD
Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Liver shows the highest level of glycerol kinase (GK) activity in humans and mice. Absence of genotype-phenotype correlations in patients with GKD indicate the involvement of modifier gen...
ORGANISM(S): Mus musculus 
2007-12-12 | E-GEOD-3843 | biostudies-arrayexpress
TranscriptomicsHistidine-Kinase Activity of the Ethylene Receptor ETR1 Facilitates the Ethylene Response in Arabidopsis
Ethylene response in Arabidopsis with wild-type or kinase-inactive ETR1
ORGANISM(S): Arabidopsis thaliana 
2012-04-01 | E-MEXP-3574 | biostudies-arrayexpress
TranscriptomicsSugar-dependent gene expression in xylose grown A. thaliana cell suspension culture
Sugars modulate expression of hundreds of genes in plants. Previous studies on sugar signaling, using intact plants or plant tissues, were hampered by tissue heterogeneity, uneven sugar transport and/or inter-conversions of the applied sugars. This, in turn, could obscure the identity of a specific...
ORGANISM(S): Arabidopsis thaliana 
2014-05-16 | E-GEOD-57751 | biostudies-arrayexpress
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