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Genomicsheat shock SUMO-2 ChIP-seq
Analysis of changes in SUMO-2 binding to chromatin in response to heat shock in human U2OS cells
ORGANISM(S): Homo sapiens 
2015-07-13 | E-MTAB-2368 | biostudies-arrayexpress
ProteomicsSMC Complexes Are Guarded by the SUMO Protease Ulp2 Against SUMO-Chain-Mediated Turnover
Structural maintenance of chromosomes (SMC) complexes, cohesin, condensin and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we show that SUMO chains target all three SMC complexes and are ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-05 | PXD022717 | Pride
Condensin Sumo chains Smc5/6 Senp/ulp proteases Cohesin Smc complexes Sumo Slx5/8 Pds5 Stubl-mediated proteasomal degradation 
ProteomicsIDENTIFICATION OF SUMO-2/3 MODIFIED PROTEINS ASSOCIATED WITH MITOTIC CHROMOSOMES
Sumoylation is essential for progression through mitosis, but the specific protein targets and functions remain poorly understood. In this study, we used chromosome spreads to more precisely define the localization of SUMO-2/3 to the inner-centromere and protein scaffold of mitotic chromosomes. We a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-10-07 | MSV000078890 | MassIVE
GenomicsDepolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
PRJNA1088517 | ENA
ProteomicsSystem-wide analysis of SUMOylation dynamics in response to replication stress reveals novel SUMO target proteins and acceptor lysines relevant for genome stability
Genotoxic agents can cause replication fork stalling in dividing cells due to DNA lesions, eventually leading to replication fork collapse when the damage is not repaired. Small Ubiquitin-like Modifiers (SUMOs) are known to counteract replication stress, nevertheless, only a small number of relevant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080851 | MassIVE
TranscriptomicsDepolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
Trypanosoma brucei are protozoan parasites that cause sleeping sickness in humans and nagana in cattle. Inside the mammalian host, a quorum sensing-like mechanism coordinates its differentiation from a slender replicative form into a quiescent stumpy form, limiting growth and virulence. SUMOylation ...
ORGANISM(S): Trypanosoma brucei 
2024-04-03 | GSE261736 | GEO
TranscriptomicsSumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation 3
mRNA profiling of WI38 expressing shCt or shUbc9 4 days post-infection. The goals of this study is to analyse transcriptionnal changes in cells were sumoylation pathway is inactivated and to compare them with ChIPseq data for several histones marks and proteins of the SUMO machinery.
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MEXP-3778 | biostudies-arrayexpress
TranscriptomicsSumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation
mRNA profiling of WI38 wild-type or overexpressiong the SUMO E3 ligase PIASy in human primary fibroblasts 24h post-infection. The goal of this study is to analyse transcriptional changes in cells over-expressing the SUMO E3 ligase PIASy and to compare them with ChIPseq data for several histones mark...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MEXP-3776 | biostudies-arrayexpress
Transcriptomicsheat shock SUMO-2 RNA-seq
RNA-seq analysis of poly-A RNA from untreated U2OS cells, and from U2OS cells exposed to heat stress (43 C) for 4 hours
ORGANISM(S): Homo sapiens 
2015-07-15 | E-MTAB-2349 | biostudies-arrayexpress
GenomicsSUMO-chain-regulated proteasomal degradation timing exemplified in DNA replication initiation
Similar to ubiquitin, SUMO forms chains, but the identity of SUMO-chain-modified factors and the purpose of this modification remain largely unknown. Here, we identify budding yeast SUMO protease Ulp2, able to disassemble SUMO chains, as a DDK interactor enriched at replication origins that promotes...
ORGANISM(S): Saccharomyces cerevisiae 
2019-09-10 | GSE113835 | GEO
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