Sort   by:  
 Page size 
GenomicsLandscape of protein SUMOylation on chromatin in hIPSCs (ChiPS4) by SUMO1 CHIP-seq
SUMO1 CHIP-seq experiment was performed in untreated hiPSC line - ChiPS4, to determine the exact locations of chromatin bound SUMO1 in these cells, thus providing information about the landscape of SUMOylation of protein targets on chromatin in human pluripotent cells and as such allowing for invest...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9960 | biostudies-arrayexpress
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
ProteomicsIdentification of covalent SUMO1 aceptor lysines
SUMO1 modified proteins were identified in a site specific manner.
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD013844 | Pride
Sumo1 Proteomics Sumo 
GenomicsTranscriptomics analysis of SUMO1 and SUMO2 U2OS knockout (KO) cell lines
Transcriptomics analysis of SUMO1 and SUMO2 U2OS knockout (KO) cell lines
PRJNA688071 | ENA
TranscriptomicsGene expression analysis in the hippocampus of SUMO1 and SUMO2 transgenic mice
Transgenic mouse lines that express His6-SUMO1 and His6-SUMO2 under the control of the neuron specific Thy1.2 promoter were generated and characterized. The effect of increased levels of SUMO1 and -2 at the level of gene expression in the hippocampus was studied. Pooled (left and right) hippocampi ...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-47951 | biostudies-arrayexpress
GenomicsChromatin modification by SUMO-1 stimulates the promoters of translation machinery genes
We determined the occupancy of SUMO-1 on chromatin in HeLa cells by use of chromatin affinity purification coupled with next generation sequencing 18 samples examined in syncrhonized HeLa cells: Cells in G1, early S (S0)/mid (S3)/ late S phase (S6), and mitosis (M), triplicates for each sample. 1 Ch...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-41264 | biostudies-arrayexpress
GenomicsSUMO and RNAPolII chromatin profiling in SUMOylation-competent and -deficient bone marrow derived dendritic cells unstimulated or stimulated with LPS
Purpose: To determine SUMO1 and SUMO2 chromatin profile in a static and dynamic manner in BMDC before and after LPS stimulation, and to determine RNAPolII chromatin occupancy in sumoylation-deficient BMDC compared to wild-type cells. Methods: SUMO1, SUMO2 and RNAPolII chromatin profiles were determi...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-66315 | biostudies-arrayexpress
GenomicsLandscape of protein SUMOylation on chromatin in hIPSCs (ChiPS4) by SUMO1 CHIP-seq
Landscape of protein SUMOylation on chromatin in hIPSCs (ChiPS4) by SUMO1 CHIP-seq
PRJEB42226 | ENA
ProteomicsSmall-molecule degraders of SUMO1 induce the protein ubiquitination and degradation through CAPRIN1-CUL1-FBXO42 ubiquitin ligase for cancer therapySmall-molecule degraders of SUMO1 induce the protein ubiquitination and degradation through CAPRIN1-CUL1-FBXO42 ubiquitin ligase for cancer therapy
Targeted protein degradation has been a long sought, but elusive, strategy for discovery of small-molecule degraders that activate E3 ubiquitin ligase-mediated ubiquitination and degradation of targeted proteins in cancer cells. Here, we report a cancer cell-based drug screen in the discovery of sma...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD022399 | Pride
Cancer Caprin1 Fbxo42 Cul1 e3 ligase Hct116 Ubiquitination Sumo1 Crispr-cas9 E3 ubiquitin ligase Sumoylation 
TranscriptomicsWhole genome RNA micro array analysis of Plasmodium berghei sporozoites infected host cells
mRNA Transcripts expression profile of Plasmodium berghei infected host HepG2 cells with and without SUMO1 over expression. To check the changes in the transcript profiles upon SUMO1 over expression which is responsible for Plasmodium berghei parasite's growth arrest in host HepG2 cells. Agilent one...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72049 | biostudies-arrayexpress
Sort   by:  
 Page size