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TranscriptomicsTranscription profiling of human HUVEC T-cell (CD40L+) induced, anti-CD40-siRNA treated
The CD40-CD40L dyad seems to play a prominent role fostering the immune-inflammatory response triggered by endothelial cell (EC)-T cell interaction. To comprehensively delineate the involvement of CD40 (TNFRSF5) in EC activation, we combined RNAi-mediated CD40 knock-down with comparative genome-wide...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-10601 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment and isomir analysis of the EGF dependent microRNA-ome by microarray and deep sequencing analysis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-06-11 | E-GEOD-41360 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and rpd3- yeast cells in response to osmotic stress
Comparison of wild type and rpd3- S. cerevisiae cells in response to osmotic stress. Wild type (MATalpha ura3 leu2 his3) and rpd3- (MATalpha ura3 leu2 his3 rpd3::KANMX) were grown to OD660=1 in YPD media and then subjected or not to a brief osmotic stress (5 or 20 min / 0.4 M NaCl). Cells were colle...
ORGANISM(S): Saccharomyces cerevisiae 
2004-01-22 | E-MEXP-48 | biostudies-arrayexpress
TranscriptomicsNP-18 vs. NP-18AR transcriptional profile upon treatment with TK/GCV
Pancreatic cancer-derived cells NP-18 underwent four rounds of treatment with increasing doses of an adenoviral vector encoding TK enzyme and GCV. Surviving cells were termed NP-18AR and displayed decreased sensitivity to treatment. This experiment analyses the transcriptomic effect of TK/GCV treatm...
ORGANISM(S): Homo sapiens 
2010-07-16 | E-GEOD-17137 | biostudies-arrayexpress
TranscriptomicsPrionic protein gene dosage is critical for maintenance of neuronal homeostasis of hippocampal circuits
We demonstrate that Prnp dosage is critical for the maintenance of neuronal homeostasis since both its absence and, more relevantly, its overexpression induce higher sensitivity to kainate (KA) damage. These data correlate with electrophysiological results in freely behaving mutant mice showing an i...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16223 | biostudies-arrayexpress
TranscriptomicsAberrant brain miRNA target and miRISC gene expression in the anx/anx anorexia mouse model
The anorexia mouse model, anx/anx, carries a spontaneous mutation not yet identified and homozygous mutants are characterized by anorexia-cachexia, growth failure and abnormal behavior, such as head weaving, hyperactivity, and ataxia. In order to test if miRNA machinery could influence the phenotyp...
ORGANISM(S): Mus musculus 
2012-12-08 | E-GEOD-26003 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse anorexia-cachexia syndrome in anx/anx mouse model
The anx/anx mouse displays poor appetite and lean appearance and is considered a good model for the study of anorexia nervosa. To identify new genes involved in feeding behavior and body weight regulation we performed an expression profiling in the hypothalamus of the anx/anx mice. Using commercial ...
ORGANISM(S): Mus musculus 
2009-05-16 | E-GEOD-11426 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis
Epidermal growth factor (EGF) is a key regulatory growth factor activating a myriad of processes affecting cell proliferation and survival that are relevant to normal development and disease. Here we have used a combined approach to study the EGF dependent transcriptome of HeLa cells. We obtained mR...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-17403 | biostudies-arrayexpress
TranscriptomicsYeast zeta-crystallin: An AU-Rich Element Binding Protein Involved in the Nutritional Stress Response
The yeast M-NM-6-crystallin Zta1p interacts specifically with RNA sequences rich in adenine and uracil (AU-rich element). We have looked for possible targets of Zta1p through a comparative transcriptional analysis of the yeast defective in ZTA1 (M-NM-^Tzta1) versus the wild-type by microarray. This ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-27 | E-GEOD-45297 | biostudies-arrayexpress
TranscriptomicsGene expression of T47D-MTVL human breast cancer cells upon H1X knock-down
Gene expression of T47D-MTVL human breast cancer cells expressing Dox-inducible shRNAs against histone H1X Stable breast cancer-derived cell lines expressing an shRNA against the histone H1X isoforms in response to doxycycline (Dox) were grown for six days in the presence or absence of Dox, and seru...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-62766 | biostudies-arrayexpress
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