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GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
UnknownA two-dimensional π-d conjugated coordination polymer with extremely high electrical conductivity and ambipolar transport behaviour.
Not available
S-EPMC4490364 | biostudies-literature
ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
UnknownHerbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10.
Not available
S-EPMC3993885 | biostudies-literature
UnknownSynthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents.
Not available
S-EPMC10834300 | biostudies-literature
UnknownMacrocycle-Antibiotic Hybrids: A Path to Clinical Candidates.
Not available
S-EPMC8120311 | biostudies-literature
TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
UnknownInhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells.
Not available
S-EPMC4043953 | biostudies-literature
UnknownSolid-phase synthesis of cyclic hexapeptides wollamides A, B and desotamide B.
Not available
S-EPMC5678967 | biostudies-literature
UnknownSuppressing mechanical property variability in recycled plastics via bioinspired design.
Not available
S-EPMC12377729 | biostudies-literature
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