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ProteomicsProteome of renal cell line caki-2 with AFMID overexpression and potential biomarker discovery in urine
Aromatic caninurine formamase (AFMID) is an enzyme involved in tryptophan pathway, metabolizing N-formylkynurenine to kynurenine. AFMID had been found significantly down regulated in clear cell renal cell carcinoma (ccRCC) in both tissue and urine samples. Although ccRCC is characterized by a typica...
ORGANISM(S): Homo Sapiens 
PXD054327 |
ProteomicsStandard operating procedure combined with comprehensive quality control system to enable large-scale urinary proteomics across multiple LC-MS platforms for precision medicine
In this study, we carried out a comprehensive evaluation of multiple LC-MS platforms in urinary proteomics including 756 proteome measurements. A series of interrelated studies was designed to assess the intra- and inter-platform consistency and reproducibility. First, we optimized the method for u...
ORGANISM(S): Homo Sapiens Escherichia Coli Saccharomyces Cerevisiae 
2024-10-28 | PXD050291 |
ProteomicsBlood and Urine-Based Liquid Biopsy for early stage cancer investigation: Taken Clear Renal Cell Carcinoma as A Model
We analyzed samples of tumor tissue, plasma, and urine from a cohort of 27 ccRCC patients with T1-2 stage and 27 matched healthy controls, using liquid chromatography–mass spectrometry (LC-MS) for proteomic analysis. We integrated the differential proteins found in the three types of samples to expl...
ORGANISM(S): Homo Sapiens 
2023-06-20 | PXD043118 |
ProteomicsComprehensive 2D-LC/MS/MS profile of normal human urinary metabolome
A comprehensivemetabolomics profile of normal human urine
ORGANISM(S): Homo Sapiens 
PXD035515 |
ProteomicsProteomic study of aqueous humor and its application in the treatment of neovascular glaucoma
We provided a comprehensive AH proteome analysis, and expanded the profile of human AH proteome. The differential AH proteomic analysis of NVG treatment indicated that AH proteome can reflect the pathophysiological changes in drug intervention.
ORGANISM(S): Homo Sapiens 
2020-07-03 | PXD020177 |
ProteomicsUrinary proteome and metabolome uncover tumor microenvironment and cellular metabolism changes of renal clear cell carcinoma
We applied LC-MS to profile the urine proteome and metabolome of 314 ccRCC, 341 healthy control and 49 kidney benign disease enrolled from three cohorts to a great depth. Functionally, we revealed significant changes of extracellular matrix (ECM) organization, complement and coagulation cascades, am...
ORGANISM(S): Homo Sapiens 
PXD064183 |
ProteomicsComprehensive Map and Functional Annotation of the Mouse White Adipose Tissue Proteome
Our data provide a large dataset of the normal mouse WAT proteome, which can be used as a baseline reference for further study.
ORGANISM(S): Mus Musculus 
2019-02-14 | PXD020169 |
ProteomicsComprehensive analysis of individual variation in the urinary proteome revealed significant gender differences
To elucidate the individual variation and related factors influencing the urinary proteome, we comprehensively analyzed the urine samples from healthy adult donors (aged 20-69 years). Co-expression network analysis revealed protein clusters representing the metabolic status, gender-related differenc...
ORGANISM(S): Homo Sapiens 
PXD013949 |
ProteomicsProteome characterization of glaucoma aqueous humour
This work describes a proteomic analysis for different types of glaucoma (PACG, NVG) and age-related cataract as control. The AH samples were recruited from 175 individual patients with PACG, NVG and age-related cataract. First, in discovery cohort the AH proteome characteristics of PAACG, PCACG and...
ORGANISM(S): Homo Sapiens 
PXD027686 |
ProteomicsCharacterization of LC-MS based urine metabolomics in healthy children and adults
In this study, we provided a comprehensive lifespan characterization of urine metabolomics in a cohort of 348 healthy children and 315 adults aged 1 to 70 years using liquid chromatography coupled with high resolution mass spectrometry.
ORGANISM(S): Homo Sapiens 
2022-06-06 | PXD034390 |
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