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GenomicsFunctional and epigenetic studies reveal multistep differentiation and plasticity of in vitro and in vivo follicular T helper cells
Follicular T helper cells (Tfh) provide critical help to B cells for germinal center (GC) formation. Mutations affecting SLAM-associated Protein (SAP) prevent GC formation due to defective T-B cell interactions, yet effects on Tfh cell differentiation remain unclear. We describe the in vitro differe...
ORGANISM(S): Mus musculus 
2012-01-05 | E-GEOD-32864 | biostudies-arrayexpress
ProteomicsHuman hepatocellular carcinoma MHCC97H proteome
In this work, we generated a MHCC97H proteome datasets by In-gel digestion on Orbitrap Fusion Lumos. We systematically compared RNC-seq and Ribo-seq in the context of proteome identification, especially when identifying protein isoforms from AS. We also demonstrated that the single-molecule long rea...
ORGANISM(S): Homo sapiens (Human) 
2022-06-28 | PXD032201 | Pride
Human In-gel digestion Liver Mhcc97h Lc-ms/ms 
ProteomicsProteomes of Spirodela polyhriza under different trophic modes
The greater duckweed (Spirodela polyrhiza 7498) exhibits trophic diversity (photoautotrophic, heterotrophic, photoheterotrophic, and mixotrophic growth) depending on the availability of exogenous organic carbon sources and light. Here, we show that the ability to transition between various trophic g...
ORGANISM(S): Spirodela Polyrhiza 
2023-02-27 | PXD040410 |
ProteomicsProteomic studies of mechanism of action of apigenin in stromal cells by five proteomic experiments
The present studies consist of five proteomic experiments: proteomic profiling treated by apigenin; DARTS coupled MS analysis to identify the potential directed proteins targets of apigenin; Identification of the potential directed protein targets of biotin-apigenin by pull-down coupled MS analysis;...
ORGANISM(S): Homo Sapiens 
2025-01-20 | PXD055761 |
ProteomicsProtective mechanisms of heparin against AGEs-induced endothelial injury
Advanced glycation end products (AGEs) in diabetes can cause endothelial damage. Heparin, widely known as a recognized anticoagulant, is also a multifunctional therapeutic drug. This study investigated whether heparin could ameliorate AGEs-induced endothelial injury. Remarkably, heparin effectively ...
ORGANISM(S): Homo Sapiens 
2025-01-19 | PXD056219 |
GenomicsBach2 represses effector programmes to stabilize Treg-mediated immune homeostasis
Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunctio...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress
ProteomicsProteome sequencing of uterus at different eggshell strenghten and thickness of hens
In this study, we employed proteomics to investigate the differences between the uteruses of laying hens with high- or low-breaking-strength shells.
ORGANISM(S): Gallus Gallus 
PXD021449 |
UnknownPrescription practices in the treatment of agitation in newly hospitalized Chinese schizophrenia patients: data from a non-interventional naturalistic study.
Not available
S-EPMC6617899 | biostudies-literature
ProteomicsSingle-cell transcriptome atlas reveals the underlying mechanism of kynurenic acid in regulation tumor immune microenvironment in glioblastoma
We performed 4D-DIA approach to quantified the proteome of GBM tissues from two groups. An average of 8880 quantified proteins were identified in each sample. In order to further explore the regulation of Kyna on GMB-resident T cells at the protein level, we performed 4D-DIA proteome analysis of CD4...
ORGANISM(S): Mus Musculus 
2025-10-30 | PXD070137 |
Proteomics5-fluorouracil (5-Fu) resistant Bel/5Fu cell line and its parent Bel7402 cell line
The extensive drug resistance of hepatocellular carcinoma (HCC) has become the main cause of chemotherapy failure. The mechanisms leading to drug resistance in tumor cells are not well understood. Previous studies demonstrated that plasma membrane proteins play important roles in mediating drug disp...
ORGANISM(S): Homo Sapiens 
2019-10-19 | PXD015917 |
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