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UnknownDiscovery of novel picolinamide-based derivatives as novel VEGFR-2 kinase inhibitors: synthesis, in vitro biological evaluation and molecular docking.
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S-EPMC6072080 | biostudies-literature
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
ProteomicsProtective mechanisms of heparin against AGEs-induced endothelial injury
Advanced glycation end products (AGEs) in diabetes can cause endothelial damage. Heparin, widely known as a recognized anticoagulant, is also a multifunctional therapeutic drug. This study investigated whether heparin could ameliorate AGEs-induced endothelial injury. Remarkably, heparin effectively ...
ORGANISM(S): Homo Sapiens 
2025-01-19 | PXD056219 |
ProteomicsAfter enriching U251 cell lysate by a lactic probe with a photo-cross linker and a corresponding control probe without lactic modification to find related reader or eraser, the protein enriched were identified by Lc-MS (three replicates)
In brief, U251 cells lysate were incubated with 10μM KpKla and 10μM KpKla separately. After incubating for 1h at 37℃, the solutions were irradiated by 365nm UV for 5 min on ice. Then CuSO4, THPTA (tris-hydroxypropyltriazolylmethylamine), TCEP (tris(2-carboxyethyl)phosphine) and biotin azide were add...
ORGANISM(S): Homo Sapiens 
2023-01-29 | PXD039731 |
ProteomicsLabel-free Quantitative Proteomics Identifies Novel Plasma Biomarkers for Distinguishing Pulmonary Tuberculosis and Latent Infection
Lack of effective differential diagnostic methods between active tuberculosis (TB) and latent infection (LTBI) is still an obstacle for TB control. Furthermore, the molecular mechanism behind the progression from LTBI to active TB has been not elucidated until now. Therefore, we performed label-free...
ORGANISM(S): Homo Sapiens 
PXD056149 |
TranscriptomicsGlobal Transcriptional Analysis of Nuclear Reprogramming in the Transition from MEFs to iPSCs
Here, we focused on the intermediate stages of SCR by comparing the somatic cell line induced by OCT4, SOX2, and KLF4 (OSK) for 7 days with mouse embryonic fibroblasts (MEFs), iPSCs, and embryonic stem cells (ESCs). Transcriptional profiles of these four cell lines were analyzed by microarray, and w...
ORGANISM(S): Mus musculus 
2012-10-01 | E-GEOD-37397 | biostudies-arrayexpress
ProteomicsRepression of EGLN1 activity by SET7-catalyzed methylation
Repression of EGLN1 activity by SET7-catalyzed methylation
ORGANISM(S): Homo Sapiens 
2022-03-08 | PXD032126 |
ProteomicsProteome of the mantle tissue of the Yesso scallop
Protiome of the mantle tissue of the Yesso scallop (Patinopecten yessoensis) is analysed based on the TMT labelling technology
ORGANISM(S): Mizuhopecten Yessoensis 
PXD033456 |
TranscriptomicsAn Automated, High Platform for Induced Pluripotent Stem Cell Derivation, Characterization and Differentiation
Induced pluripotent stem cells (iPSCs) have become an essential tool for both modeling how causal genetic variants impact cellular function in disease, as well as being an emerging source of tissue for transplantation medicine. Unfortunately the preparation of somatic cells, their reprogramming and ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-69868 | biostudies-arrayexpress
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