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ProteomicsThe identification of ubiquitination sites of IBTK by shotgun proteomics
Previous study reported that eIF4A1 protein stability is subject to control by the ubiquitin-proteasome pathway, and deubiquitinase USP9X elevated eIF4A1 protein level by promoting eIF4A1 deubiquitination. However, the E3 ubiquitin ligases responsible for eIF4A1 proteolysis is not determined. Our re...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD039031 | Pride
Ibtk Ubiquitination Shotgun 
ProteomicsDefine the interactome of IBTK by Affinity purification coupled with mass spectrometry (AP-MS) and proximity-dependent biotinylation identification (BioID) methods
Affinity purification coupled with mass spectrometry (AP-MS) and proximity-dependent biotinylation identification (BioID) methods are powerful tools to define the interactome for a specific protein bait. Whereas AP-MS results in the identification of proteins that are in a stable complex, BioID labe...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD038286 | Pride
Ap-ms Ibtk interactome Bioid 
ProteomicsNon-small cell lung cancer-associated Keap1 mutations lead to epigenetic reprogramming and tumorigenesis through CHD6 stabilization
The E3 ubiquitin ligase substrate recognition subunit Keap1 mediates the ubiquitination and degradation of the oxidative stress transcription factor NRF2. Approximately 30% of non-small cell lung cancers (NSCLCs) harbor inactivating mutations in Keap1 or activating mutations in NRF2, both of which l...
ORGANISM(S): Homo sapiens (Human) 
2026-09-11 | PXD060256 | Pride
Non-small lung cancer、chd6、oxidative stress 
ProteomicsIdentify the interacting proteins of FBXL4 by AP-MS
Affinity purification coupled with mass spectrometry (AP-MS) is powerful tools to define the interactome for a specific protein bait. Whereas AP-MS results in the identification of proteins that are in a stable complex.Mass spectrometry was performed to identify the interacting proteins of FBXL4 fro...
ORGANISM(S): Homo sapiens (Human) 
2024-05-12 | PXD040601 | Pride
Human Fbxl4 Ap-ms 
Proteomicsproteome sequencing of Triticum aestivum L
The 15 DAP and 20 DAP endosperm samples from WT and lgp1 seeds were used for tandem mass tag (TMT) proteasome analysis. Three biological replicates were used for each genotype
ORGANISM(S): Triticum Aestivum 
PXD027683 |
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