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Proteomicscomparative proteomics of non-small cell lung cancer and small cell lung cancer
We aimed to identify the differences between these two subtypes of lung cancers and their differentially clinical treatment. Through functional analysis, we obtained differentially expressed proteins which might be assossciated with lung cancer treatment.
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD015270 | Pride
Lung cancer Proteomics Lc-mc/mc 
ProteomicsCordycepin Delays Postovulatory Aging of Mammalian Oocytes through Inhibition of Maternal mRNAs Degradation via DCP1A Polyadenylation Suppression
Postovulatory aging leads to the decline in oocyte quality and subsequent impairment of embryonic development, thereby reducing the success rates of assisted reproductive technology (ART). Nevertheless, potential preventative strategies to improve aging oocytes quality and the associated underlying ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD042600 | Pride
Aging oocytes Cordycepin 
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
ProteomicsProteomics analysis of the myocardium form chronic hypobaric hypoxia-induced mice model
C57BL/6J mice were assigned to the hypobaric hypoxia chamber for simulation of high-altitude conditions. iTRAQ proteomics analysis/nanoUHPLC-MS/MS analysis was performed accordingly in the right myocardium of mice that had been allowed to develop hypoxia-induced pulmonary hypertension after hypobari...
ORGANISM(S): Mus Sp. 
2023-02-23 | PXD040342 |
ProteomicsCRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells
We develop a CRISPR-Assisted RNA-Protein Interaction Detection method (CARPID), which leverages CRISPR/CasRx-based RNA targeting and proximity labeling to identify binding proteins of specific lncRNA in the native cellular context.
ORGANISM(S): Homo Sapiens 
2020-05-20 | PXD015702 |
MetabolomicsSensing Ceramides by CYSLTR2 and P2RY6 to Aggravate Atherosclerosis

Recent evidence shows elevated circulating long-chain ceramide levels predicts atherosclerotic cardiovascular disease (ASCVD) independently of cholesterol. Although targeting ceramides signaling may provide therapeutic benefits beyond the treatment of hypercholesterolemia, the underlying mechanis...

2025-04-15 | MTBLS11925 | MetaboLights
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