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ProteomicsIdentification of missing proteins in the proteome atlas of multiple healthy human tissues
We re-analyzed the deep proteome atlas of 29 paired healthy human from the published paper (Wang, Dongxue, et al. Molecular systems biology 15.2 (2019)) to identify missing proteins.
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD021391 | Pride
Chpp Open-pfind Missing proteins Mutiple tissues 
ProteomicsOpen-pFind Enhances the Identification of Missing Proteins from Human Testis Tissue
In recent years, high-throughput technologies have contributed to development a more precise picture of the human proteome. However, 2,129 proteins remain listed as missing proteins (MPs) in the newest neXtProt release (2019-02). The main reasons for MPs are a low abundance, low-molecular-weight (LM...
ORGANISM(S): Homo sapiens (Human) 
2019-11-04 | PXD015759 | Pride
Testis Open-pfind，efficiency Chromosome-centric human proteome project Missing proteins 
ProteomicsQuantitative Proteomics Reveals Dormancy Related Proteins Mediated Attenuation Program in Mycobacterium Strain
To better understand the virulence difference among different MTB strains and identify new targets for therapeutic intervention under hypoxia condition, we compared the global protein expression at the protein level by quantitative proteomics among H37Rv, H37Ra and BCG.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2022-04-04 | PXD023788 | Pride
Tmt10tags Mycobacterium tuberculosis Qe-hf 
ProteomicsQuantitative Proteomics Reveals Dormancy Related Proteins Mediated Attenuation Program in Mycobacterium Strain
To better understand the virulence difference among different MTB strains and identify new targets for therapeutic intervention under hypoxia condition, we compared the global protein expression at the protein level by quantitative proteomics among H37Rv, H37Ra and BCG.
ORGANISM(S): Mycobacterium tuberculosis Mycobacterium tuberculosis complex 
2022-04-01 | PXD017174 | Pride
Mycobacterium tuberculosis Tmt Virulence，quantitative proteomic 
ProteomicsIntegrated multi-omic analysis of Mycobacterium tuberculosis isolates identifies ethionamide resistance-associated gene pair Rv3094c-Rv3095
Global control of the tuberculosis (TB) epidemic is seriously threatened by increasing prevalence of drug resistant (DR) M. tuberculosis (MTB) isolates. Many genome-wide studies have identified DR-associated SNPs and investigated their role in DR mechanisms. However, DR in ~30% of isolates has no cl...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2023-03-10 | PXD017079 | Pride
Transcriptome Mycobacterium tuberculosis Drug resistance Lineage Proteome Baeyer-villiger monooxygenase Phylogenetics Ethionamide Rna-seq 
ProteomicsQuantitative proteomics of Chromochloris zofingiensis reveals key protein involved in cell growth and bioactive compound biosynthesis
Glucose metabolism regulates cell growth and affects astaxanthin accumulation in green algae Chromochloris zofingiensis. Hub genes function in this bioactive compound biosynthesis has been illustrated in genome, transcriptome and metabolome level, but rather limited from proteome aspects. Microalgal...
ORGANISM(S): Chromochloris Zofingiensis 
2022-06-13 | PXD034488 |
Proteomics2018CHPP
ABSTRACT Since 2012, Chromosome-Centric Human Proteome Project (C-HPP) launched the journey of missing proteins (MPs) investigation for completing human proteome project (HPP). We found the majority of MPs were distributed in low molecular weight (LMW) ranges, especially in 0-40 kDa. The identificat...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-14 | MSV000083978 | MassIVE
ProteomicsHuman testis off-line LC-MS/MS
In order to identify more MPs and get deeper proteomic data of testis. We applied high-pH reverse phase (RP) HPLC to fractionate complex samples.On the other hand, to enhance protein coverage, multi-protease strategies were used for 10% SDS-PAGE short separation samples.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-19 | MSV000086491 | MassIVE
ProteomicsAc-LysargiNase Helps Genome Reannotation of Mycolicibacterium smegmatis MC2 155
To achieve deep coverage of M. smegmatis proteome, 240 μg proteins were reduced with 5 mM of dithiothreitol (DTT), alkylated with 20 mM of iodoacetamide (IAA). The alkylated proteins were separated by a 10% SDS-PAGE for 8 cm, and stained with Coomassie Blue G250. Gel lane was excised into 13 fractio...
ORGANISM(S): Mycolicibacterium Smegmatis Mc2 155 
2022-09-29 | PXD037080 |
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