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MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
GenomicsAntibiotic Resistance Profile and Genomic Characteristics of Multidrug-Resistant Bacteria from the Sludge of a Pharmaceutical Wastewater Treatment Plant
Incomplete antibiotic removal in pharmaceutical wastewater treatment plants (PWWTPs) could lead to the development and spread of antibiotic-resistant bacteria (ARBs) and genes (ARGs) in the environment, posing a growing public health threat. In this study, two multiantibiotic-resistant bacteria, Och...
ORGANISM(S): mixed sample 
2024-10-20 | E-MTAB-14497 | biostudies-arrayexpress
TranscriptomicsGene profiles of pathway interference downstream neurofibromin signaling
Malignant peripheral nerve sheath tumor (MPNST) is a type of soft tissue sarcoma that occurs in carriers of mutations in the neurofibromatosis type I gene (Nf1) as well as sporadically.　Plexiform neurofibromas in NF1 patients have a significant risk of developing into MPNSTs leading to increased mor...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-GEOD-39764 | biostudies-arrayexpress
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
MetabolomicsAbsolute quantification of serum cytokines and metabolome reveals the glycylproline regulating antibody-fading in convalescent COVID-19 patients

The COVID-19 pandemic has incurred tremendous costs worldwide and is still threatening public health in the 'new normal'. The association between neutralizing antibody levels and metabolic alterations in convalescent patients with COVID-19 is still poorly understood. In the present work, we condu...

2024-08-26 | MTBLS3305 | MetaboLights
TranscriptomicsDifferential Expressions of miRNAs in resting and activated human in vitro-differentiated NK cells
To investigate miRNA expressions of miRNA upon activation. In vitro-differentiated human NK cells were freshly incubated in the presence of IL15 after 24h deprivation of IL-15. The cells were harvested at the times (0h, resting-Sample 1 and 2; 6h, activated-Sample 3 and 4) and analyzed by microarray...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-32411 | biostudies-arrayexpress
ProteomicsHDX-MS analysis of PTPN2 with the CRBN/DDB1 complex
We used HDX-MS analysis to analyze the interaction between PTPN2 with a compound both in the presence and absence of the CRBN/DDB1 complex. We identified significant changes in HDX when PTPN2 was in the presence of compound. We also identified significant changes when comparing the deuteration profi...
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD053867 | Pride
Hdx-ms Ptpn2 Crbn Ddb1 
UnknownAssociation of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts.
Not available
S-EPMC9846698 | biostudies-literature
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
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