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This study aims to define the landscape of somatic mutations in sun exposed human skin by deep sequencing, analyse their frequency and use the data to infer the effect of mutations on proliferating cell behaviour. The frequency of each mutation will reflect the size of the clone of cells in the tiss...
This study aims to define the landscape of somatic mutations in sun exposed human skin by deep sequencing, analyse their frequency and use the data to infer the effect of mutations on proliferating cell behaviour. The frequency of each mutation will reflect the size of the clone of cells in the tiss...
Our recent work showed COVID BALF from vaccinated individuals contained significantly lower concentration of fibrinogen and prothrombin, suggesting a potential benefit of vaccination being lower risk of fibrin clotting and acute lung injury. As our previous mass spec-based proteomic ID approach show...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD066557 | Pride
Deep sequencing of two skin biopsies to study the landscape of somatic mutations in human adult tissues.
This study aims to define the landscape of somatic mutations in sun exposed human skin by deep sequencing, analyse their frequency and use the data to infer the effect of mutations on proliferating cell behaviour. The frequency of each mutation will reflect the size of the clone of cells in the tiss...
This study aims to define the landscape of somatic mutations in sun exposed human skin by deep sequencing, analyse their frequency and use the data to infer the effect of mutations on proliferating cell behaviour. The frequency of each mutation will reflect the size of the clone of cells in the tiss...
Purpose: To determine global gene expression changes following siRNA knockdown of Myc, Kcnk1, and Snta1 compared to non-targeting siRNAs or mock-transfected cells Methods: Total RNA was processed using the Illumina TruSeq Stranded mRNA Sample Preparation Kit according to manufacturer’s protocol. Gen...
ORGANISM(S): Homo sapiens 
Transfer RNA (tRNA) modifications have emerged as critical posttranscriptional regulators of gene expression that impact diverse biological and disease processes. While there is extensive knowledge about the enzymes installing the dozens of tRNA modifications – the tRNA epitranscriptome – very littl...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2025-08-04 | PXD053297 | Pride
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