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MetabolomicsPrenatal exposure to trace elements impacts mother-infant gut microbiome, metabolome and resistome during the first year of life

Infancy is a critical period for the colonization of the gut microbiome. However, xenobiotic effects on gut microbiome development in early life remain poorly understood. Here, we recruit 146 mother-infant pairs and collect stool samples at 3, 6, and 12 months after delivery for amplicon sequenci...

2025-05-02 | MTBLS11392 | MetaboLights
ProteomicsMass spectrometry of human A549 cells transfected with EBV BRLF1
The immediate-early protein BRLF1 plays important roles in lytic infection of Epstein-Barr virus (EBV), in which it activates lytic viral transcription and replication. However, knowledge of the influence of BRLF1 on cellular gene expression and transcriptional reprogramming during the early lytic c...
ORGANISM(S): Homo Sapiens 
2020-10-13 | PXD021958 |
MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
ProteomicsTargeting RANKL-Independent Osteoclastogenesis Overcomes Denosumab Resistance in ER+ Breast Cancer Bone Metastasis
Bone metastasis remains a major cause of morbidity in ER+ breast cancer, with RANKL inhibitor resistance emerging as a critical clinical challenge. Nearly 40% of patients develop progressive skeletal lesions despite denosumab therapy, highlighting an urgent need to identify resistance mechanisms and...
ORGANISM(S): Homo Sapiens 
2026-01-29 | PXD073739 |
ProteomicsLabel-free quantitative proteomics for screening dynamic autophagy-related proteins during nutrient deprivation in MEFs
A Label-free quantitative proteomic profiling was performed on MEFs with or without nutrient starvation.
ORGANISM(S): Mus Musculus 
PXD025450 |
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