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ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of a Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared with the wild-type ...
ORGANISM(S): Plasmodium berghei ANKA 
2025-06-27 | PXD053412 | Pride
Plasmodium  ser/thr protein phosphatase 6  gametogenesis  ca2+ signaling cascade  pkg 
ProteomicsInvestigating the conformational changes of OEA on HIF-3A-ARNT by HDX-MS
We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to investigate the influence of OEA on HIF-3A-ARNT.HDX-MS data indicated that OEA binding stabilized multiple residues within the Gβ and Fα regions of HIF-3A PAS-B domain.It is possible that the stabilized Gβ and Fα function as an “inter...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD033376 | Pride
Oea Hdx-ms Hif-3a-arnt 
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared to wild-type P. b...
ORGANISM(S): Plasmodium berghei 
2025-06-27 | PXD063164 | Pride
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite plasmodium berghei 
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
ProteomicsApoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway
The purpose of this study is to investigate the therapeutic effect of MSC-derived apoVs treatment on NIHL and the potential mechanism of resisting oxidative stress damage in hair cells, as well as the distribution of apoptotic vesicles in the inner ear. The study provided a new direction for the tre...
ORGANISM(S): Homo Sapiens 
2023-03-20 | PXD040989 |
ProteomicsDiscovery of 180055 as a PROTAC degrader for Treating Cancers
PARP1 is an abundant nuclear protein that is involved in a number of biological processes linked to cellular stress responses. PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). In this work we discovered a PROTAC degrader of PA...
ORGANISM(S): Homo Sapiens 
2023-05-18 | PXD042311 |
ProteomicsIsotope and proteomics evidence for ancient mobility and sex bias of Pre-Pottery Neolithic Jericho in Southern Levant
The transition from mobility to more sedentism is one of the essential processes at the pre-pottery stage of human societies, which takes place asynchronously in different communities in different regions. Being one of the representatives and long-termly occupied sites in the southern Levant, Jerich...
ORGANISM(S): Homo Sapiens 
2022-10-08 | PXD037215 |
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
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