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ProteomicsElusive elapid: Biogeographic venom variation in Indian kraits and its repercussion on snakebite therapy
Snakebite is a major public health concern in many parts of the world, including India, where over 58,000 deaths occur annually due to this highly neglected tropical disease. The common krait (Bungarus caeruleus), one of the ‘big four’ Indian snakes, is responsible for the second-highest number of s...
ORGANISM(S): Bungarus caeruleus 
2024-11-02 | PXD052611 | Pride
Orbitrap triple fusion Mass spectrometry Snakebite Snake venom Common krait Bungarus caeruleus 
ProteomicsExplaining Echis envenoming: Transcriptomic and proteomic profiling of Echis carinatus venom
In India, venom research has largely focussed on the ‘big four’ snakes that are greatly responsible for the burden of snakebite in the Indian subcontinent. This study aims to advance understanding of saw-scaled viper venoms from India, we implemented a multi-faceted approach. We sequenced the venom ...
ORGANISM(S): Echis carinatus 
2025-08-04 | PXD064002 | Pride
Antivenom In vivo Proteome Echis carinatus Transcriptome 
ProteomicsThe preclinical evaluation of a second-generation antivenom for treating snake envenoming in India
In this study, by employing chromatographic purification of the bulk, we have significantly enhanced the preclinical performance of the conventional Indian antivenom product. The effectiveness of the test batches of this ‘second-generation’ antivenom was evaluated using a variety of in vitro and in ...
ORGANISM(S): Equus caballus (Horse) 
2022-04-04 | PXD029436 | Pride
Snakebite Antivenoms Second-generation antivenoms 
ProteomicsStings on wings: venom proteomics and tissue transcriptomics of the lesser banded hornet, Vespa affinis
The project aims at unraveling the venom repertoire of the lesser banded hornet (Vespa affinis) and investigate the regimes of natural selection underpinning their venom evolution. The study also sheds light on the clinical repercussions of the V. affinis venom.
ORGANISM(S): Vespa affinis 
2023-03-10 | PXD037171 | Pride
Vespa affinis Wasp venom Arthropod venom Venom gland transcriptome Venom proteome 
ProteomicsTo the islands their own: Venomics of the enigmatic Andaman cobra (N. sagittifera) and the preclinical failure of Indian antivenoms in Andaman and Nicobar Islands
In this study, we unveil the venom composition, biochemistry, pharmacological activity, and potency of the Andaman cobra (N. sagittifera).
ORGANISM(S): Naja naja Naja sagittifera 
2022-02-17 | PXD025362 | Pride
Naja sagittifera Proteomics Indian antivenoms Naja naja 
ProteomicsFangs in the ghats: preclinical insights into the medical importance of endemic pit vipers from the Western Ghats
The socioeconomic burden of snakebite in India is largely attributed to the ‘big four’ snakes, completely neglecting the considerable impact of envenoming by many other snake species. Bites from the so-called ‘neglected many’ are often treated with a polyvalent antivenom that is manufactured against...
ORGANISM(S): Trimeresurus malabaricus Trimeresurus gramineus Hypnale hypnale 
2023-07-20 | PXD039139 | Pride
Craspedocephalus gramineus Preclinical research Craspedocephalus malabaricus Hypnale hypnale 
ProteomicsA wolf in another wolf’s clothing: Post-genomic regulation dictates venom profiles of medically-important cryptic kraits in India
This study investigates the widespread cryptic Bungarus caeruleus (Comman krait) in India and clinical repercussions of their bits by implementing multidisciplinary approach involving proteomics, transcripomics, and assessment of toxicity and efficacy of currently marketed anivenoms. The study also ...
ORGANISM(S): Bungarus 
2021-09-09 | PXD023127 | Pride
Bungarus venom Proteomics Transcripomics Snake venoms 
ProteomicsThe Arabian cousin: Comparative venomics of Daboia palaestinae and Daboia russelii
In this study, to unravel the influence of phylogenetic divergence and biogeography in shaping the composition and activity of Daboia venoms, we comparatively investigated the venoms of D. russelii from western India and D. palaestinae from Israel.
ORGANISM(S): Daboia russelii Daboia palaestinae 
2023-03-11 | PXD031190 | Pride
Daboia palaestinae  daboia russelii  venomics  transcriptomics  preclinical assessment 
ProteomicsBiogeographic venom variation in medically important Indian snakes and the inadequacy of antivenom therapy in snakebite hotspots
The project aims at investigating the snake venom variability of Daboia russelii populations from five different biogeographic zones across India.
ORGANISM(S): Daboia russelii 
2021-02-26 | PXD021060 | Pride
Venom variation Snake venoms Daboia russelii venom Venomics 
ProteomicsHiss of death - Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy
The project aims at investigating the snake venom variability of Naja naja populations from six different biogeographic zones across India.
ORGANISM(S): Naja naja 
2021-02-10 | PXD020497 | Pride
Venom variation Snake venoms Naja naja venom Venomics 
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