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In the present study, we carried out in-depth proteomic analysis of a clinical isolate of post kala-azar dermal leishmaniasis (PKDL) L. donovani promastigotes. The high-resolution mass spectrometry data was searched against protein database of L. donovani. This resulted in identification of 5, 283 u...
ORGANISM(S): Leishmania donovani Ld 2001 
2022-03-13 | PXD020541 | Pride

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
To identify biomarkers specific for Miltefosin resistant parasites, we used DNA microarray to identify differentially expressed genes in resistant parasite in comparision to sensitive and further validated with real time PCR assay and immunoblotting assay Clinically proven miltefosine reistant as we...
ORGANISM(S): Leishmania donovani 
Reprogramming of the androgen receptor (AR) cistrome is associated with disease progression, and advanced castrate-resistant prostate cancers (CRPC) tend to rely on a reprogrammed/non-canonical AR signaling that is addictive to AR signaling inhibitor (ARSI) resistance. We identified EVI1, an oncogen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD062331 | Pride
WTCCC2 Visceral Leishmaniasis samples from Brazil using Illumina 670k
WTCCC2 Visceral Leishmaniasis samples from Sudanl using Illumina 670k
WTCCC2 Visceral Leishmaniasis samples from Indial using Illumina 670k
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