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UnknownIFITs: Emerging Roles as Key Anti-Viral Proteins.
Not available
S-EPMC3948006 | biostudies-literature
TranscriptomicsGene expression profiling of interferon-beta stimulated cells
Cytoplasmic DNA triggers the activation of the innate immune system. While downstream signaling components have been characterized, the DNA sensing components remain largely elusive. We performed a systematic proteomics screen for proteins that associate with DNA, traversed to a screen for IFN-β-ind...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-14413 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of wild-type HEK293 and K562 celllines
RNA-Seq was carried out in order to obtain the expression profile of Solute Carrier Family (SLC) of proteins in two commonly used celllines. We were specifically interested in the subset of SLCs that are capable of transporting amino acids.
ORGANISM(S): Homo sapiens 
2015-01-07 | E-MTAB-3102 | biostudies-arrayexpress
MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsBioID proximity biotinylation-MS analysis of human main RAS GTPases in K-562 CML cells
The human main RAS GTPases (KRAS4A, KRAS4B, NRAS and HRAS) represent major hubs of cellular signal transduction and are highly mutated in various different cancer entities. RAS GTPases are tightly controlled via different molecular mechanisms in order to coordinate their cellular signaling activity ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-03 | PXD011280 | Pride
Ras gtpases Cml Lc-ms Bioid 
ProteomicsA novel inducible retroviral expression system for StrepHA-tandem affinity purification mass-spectrometry-based proteomics
Tandem-affinity purification mass spectrometry using the streptavidin-hemagglutinin (SH)-tag has been successfully employed to map signaling networks in several large-scale studies. However its application has so far been restricted to the small number of Flp/FRT-recombination competent cell lines....
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2016-01-05 | PXD002855 | Pride
Tandem affinity purification-mass spectrometry Protein-protein interaction Streptavidin-hemagglutinin-tag 
MetabolomicsMetabolic mapping of the human solute carrier superfamily

Solute carrier (SLC) transporters govern most of the chemical exchange across cellular membranes and are integral to metabolic regulation, which in turn is linked to cellular function and identity. Despite their key role, individual functions of the SLC superfamily members were not evaluated syst...

2025-07-22 | MTBLS11393 | MetaboLights
ProteomicsQuantitative proteome profiling in HEK293 to validate RNAi targets
The solute carrier (SLC) transporter superfamily are important coordinators of metabolic and cellular homeostasis. Despite their importance for cellular homeostasis, SLCs remain a largely understudied group of proteins regarding their protein interactome. Thus, we conducted a largescale interactome ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD055192 | Pride
Dia Slc interactors Validation of sirnas Full proteome 
ProteomicsInteraction proteomics of wildtype SLC16A6 (MCT7) and phospho-variants
The solute carrier (SLC) transporter superfamily are important coordinators of metabolic and cellular homeostasis. Despite their importance for cellular homeostasis, SLCs remain a largely understudied group of proteins regarding their protein interactome. Thus, we conducted a largescale interactome ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD055141 | Pride
Phosphodegron Slc16a6 phsopho-variants Ap-ms 
ProteomicsInteraction proteomics of WT and disease variants of the human Creatine Transporter (SLC6A8)
Creatine is an essential metabolite for the storage and rapid supply of energy in muscle and nerve cells. In humans, the creatine deficiency syndrome (CDS) is manifested by impaired metabolism, transport, and distribution of creatine throughout the body leading to severe forms of mental disabilities...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD047111 | Pride
Ap-ms Slc6a8 Protein interactions Pathogenic variants 
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