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MetabolomicsSpatiotemporal determination of metabolite activities in the corneal epithelium on a chip
The corneal epithelial barrier maintains the metabolic activities of the ocular surface by regulating membrane transporters and metabolic enzymes responsible for the homeostasis of the eye as well as the pharmacokinetic behavior of drugs. Despite its importance, no established biomimetic in vitro me...
2021-07-13 | MTBLS2274 | MetaboLights
TranscriptomicsExpression data from mouse ALDH1 positive and ALDH1 negative ovarian surface epithelium (OSE) cells
The hilum region of the mouse ovary, the transitional/junction area between OSE, mesothelium and tubal (oviductal) epithelium is identified as a previously unrecognized stem cell niche of the OSE. OSE cells with high ALDH1 activity have been predominantly detected in the hilum region by immunohistoc...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43897 | biostudies-arrayexpress
TranscriptomicsWnt ligands from the embryonic surface ectoderm regulate bimetallic strip optic cup morphogenesis in the mouse
Wnt signaling in early eye development, specifically the lens placode shows expression of 12 out of 19 Wnt ligands. We these Wnt activities were suppressed using conditional deletion of Wntless, dramatic phenotypic changes in morphogensis occurred. Microarray analysis of the genes that were changed...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-65154 | biostudies-arrayexpress
ProteomicsFibrosis associated changes detected in the proteome of surface epithelium overlying Crohn’s Disease Strictures
Background and aims: Intestinal fibrosis is a common complication of Crohn’s disease (CD). It is characterised by an excessive accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive extracellular matrix. The potential role of the intestinal epithelium in this f...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD022214 | Pride
Inflammatory bowel disease Label free proteomics Surface epithelium Fibrostenosis Ileum 
TranscriptomicsTranscriptome Profiling of Lgr5-expressing ovarian surface epithelium cells
Transcriptome profiling using Affymetrix GeneChip arrays was performed on sorted populations of Lgr5-expressing mouse ovarian surface epithelium. The ovary surface epithelium (OSE) undergoes ovulatory tear-and-remodelling throughout life. Resident stem cells drive such tissue homeostasis in many adu...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52925 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of olfactory epithelium isolated from wild type and SR-A mutant mice at different time points after bilateral olfactory bulbectomy to understand the temporal gene expression patterns.
Sham and bilateral OBX were performed on wild-type and SR-A mutant mice. Tissue collected 2, 8, 16, and 48 hours following OBX. Expression profiles were determined using Affynetrix MG U74Av2 chips. Experiment Overall Design: olfactory epithelium from 3 wild type 6 week old mice and 3 SR-A 6 week old...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-3455 | biostudies-arrayexpress
GenomicsTranscriptional profile of stemness in the ovarian surface epithelium
Transcriptional profile of stemness in the ovarian surface epithelium
PRJNA506731 | ENA
TranscriptomicsExpression data from high-grade serous ovarian carcinomas (HGSC), clear cell ovarian carcinomas (CCC) and ovarian surface epithelium (OSE)
Background: The aim of this study was to identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovarian carcinoma (CCC) and ovarian surface epithelium (OSE). Selected miRNAs were evaluated for association with clinical parameters including survival, and mi...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47841 | biostudies-arrayexpress
ProteomicsBovine sperm surface lectinome
Identification of bovine sperm surface carbohydrate-binding proteins relevant in two important aspects of fertilization: (i) formation of the sperm reservoir in the oviductal epithelium, and (ii) gamete recognition (oocyte-sperm interaction). Using whole sperm cells and a novel affinity capture meth...
ORGANISM(S): Bos taurus (Bovine) 
2016-04-28 | PXD003386 | Pride
Bovine Sperm Lectins Fertilization 
TranscriptomicsUstilago maydis gene expression after growth on hydrophobic surface plus/minus hydroxy fatty acids
Infection-related development of phytopathogenic fungi is initiated by sensing and responding to plant surface cues. This response results in the formation of specialized infection structures, so-called appressoria. To unravel the program inducing appressoria in the biotrophic smut fungus Ustilago m...
ORGANISM(S): Ustilago maydis 
2014-07-23 | E-GEOD-53947 | biostudies-arrayexpress
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