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TranscriptomicsHistone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its SRI domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 recruits the Rpd3S histone deacetylase complex to repress crypt...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-04 | E-GEOD-66821 | biostudies-arrayexpress
TranscriptomicsMax as a biological blockade that restricts meiotic process in ESCs
We explored Max ablation-mediated up-regulation of germ-related genes, especially meiosis-related genes in mouse embryonic stem cells which were cultured either under conventional mouse ES medium or 2i condition using inhibitors against MEK and GSK3b. Effect of culture conditions (conventional mouse...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-65700 | biostudies-arrayexpress
TranscriptomicsIdentification of Ccr4-Not complex as a regulator of transition from partial to genuine iPS cells
Partial induced pluripotent cells (iPSCs) are cell lines strayed from normal route from somatic cells to iPSCs and are immortalized. Mouse partial iPSCs are able to convert to real iPSCs by the exposure to 2i condition using MAPK and GSK3? inhibitors. However, the molecular mechanisms of this conver...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-44339 | biostudies-arrayexpress
TranscriptomicsThe forced expression of Nanog or Esrrb allows preserve ESC status in the absence of nucleostemin expression
Nucleostemin (NS) gene is known to be expressed in stem cells in general including embryonic stem cells (ESCs). Previous knockdown and knockout studies have demonstrated that NS is important for the preservation of their self-renewality and high levels of pluripotent marker gene expression in mouse ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-56797 | biostudies-arrayexpress
UnknownDiagnostic performance of a novel digital immunoassay (RapidTesta SARS-CoV-2): A prospective observational study with nasopharyngeal samples.
Not available
S-EPMC8549190 | biostudies-literature
TranscriptomicsDevelopment and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of TGFβ1 as the major player in the pathogenesis of the disease. This study designed novel human- and mouse-specific siRNAs and siRNA/DN...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-28122 | biostudies-arrayexpress
ProteomicsK562 cell lysates prefractionated by various methods
K562 cell lysates were prefractionated by protein reversed-phase chromatography (Prot-RP), SDS-PAGE, and high-pH peptide RP (Pept-RP) to compare their method characteristics. The starting material was prefractionated to 10 fractions for each method. Each prefractionation method was conducted in trip...
ORGANISM(S): Homo Sapiens (human) 
2024-10-15 | PXD049312 | JPOST Repository
ProteomicsTime-resolved analysis of vUNG phosphorylation
Time-resolved phosphoproteomic analysis of HEp-2 cells infected with wild type HSV-1(F)
ORGANISM(S): Cellular Organisms 
2025-06-03 | PXD055199 | JPOST Repository
ProteomicsMS-based determination of vUNG phosphorylation
Phosphoproteomic analysis of HEp-2 cells infected with wild type HSV-1(F)
ORGANISM(S): Cellular Organisms 
2025-06-03 | PXD043453 | JPOST Repository
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