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TranscriptomicsGlobal analysis of gene expression by SV40 T antigen in mouse embryo fibroblasts
SV40 large T antigen (TAg) contributes to cell transformation, in part, by targeting two well characterized tumor suppressors, pRb and p53. TAg expression affects the transcriptional circuits controlled by Rb and by p53. We have performed a microarray analysis to examine the global change in gene ex...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-20620 | biostudies-arrayexpress
ProteomicsDissecting the effect of a long linker DNA on protein binding to di-nucleosomes decorated with promoter-associated PTMs
Characteristic features of chromatin states are not limited to particular epigenetic modifications but include other regulatory cues, such as linker DNA length, typically ranging from around 35-55 bp in most eu- and heterochromatin domains (Valouev et al, 2011; Voong et al., 2016, Cell) to over 200 ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD041835 | Pride
Ndrs Sv40 promoter H3k4me3 Pull-down H4ac H3ac 
TranscriptomicsTranscription profiling of rat REF52 cells expressing SV40 T antigens
SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and survival by action on multiple proteins, including the tumor suppressors Rb and p53. Large T antigen al...
ORGANISM(S): Rattus norvegicus 
2009-09-12 | E-GEOD-7836 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [aCGH]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-31097 | biostudies-arrayexpress
TranscriptomicsHuman Corneal Epithelial Cells (SV40-HCEC) 6h Treatment with 100nM Vitamin D (1,25D3) vs. Vehicle Control
Inflammatory signals must be regulated and kept in check in order to prevent tissue damage.  This is especially true in the cornea, where damage can induce loss of transparency, essential for vision.  Toll-like receptors (TLRs) are present at the ocular surface and, in addition to being protective...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72663 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-29117 | biostudies-arrayexpress
TranscriptomicsWild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation
To measure on a global scale the SV40 large T antigen-mediated changes in gene transcription in mouse embryo fibroblasts differing in the expression of p53. Samples of total RNA from 3T3 (wt p53) and 10-1 (p53-null) mouse embryo fibroblasts stably transfected with SV40 large T-antigen expressing pMY...
ORGANISM(S): Mus musculus 
2009-07-18 | E-GEOD-17178 | biostudies-arrayexpress
TranscriptomicsInvoluted normal mammary gland in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-33038 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice
This SuperSeries is composed of the following subset Series: GSE29117: Mammary carcinomas in WAP-SV40 transgenic mice [gene expression] GSE31097: Mammary carcinomas in WAP-SV40 transgenic mice [aCGH] GSE33038: Involuted normal mammary gland in WAP-SV40 transgenic mice [gene expression] Refer to indi...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-31212 | biostudies-arrayexpress
UnknownThe Influence of SV40 polyA on Gene Expression of Baculovirus Expression Vector Systems.
Not available
S-EPMC4686012 | biostudies-literature
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