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UnknownCohort profile: radiotherapy dataset (RTDS) in England.
Not available
S-EPMC10314480 | biostudies-literature
TranscriptomicsNucleosome eviction in mitosis assists condensin loading and chromosome condensation
The experiment was performed to assess the importance of nucleosome eviction for the binding of condensin to chromatin during mitosis. The condensin complex associates with chromatin during mitosis to ensure chromosome condensation and accurate segregation, but how this binding is achieved remains ...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2016-04-18 | E-MTAB-4620 | biostudies-arrayexpress
GenomicsComparison of nucleosome occupancy and chromatin states between normal and cancer cell lines
Background: Epigenetic modification is a hallmark of cancer cells achieved through altered patterns of DNA methylation, histone modifications and nucleosome positions. These events have only been described in detail at gene promoters. Results: Here, we integrate multiple epigenome-wide maps to eval...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-57498 | biostudies-arrayexpress
GenomicsDynamics of yeast ISWI and CHD chromatin remodeler genomic association (part 1)
Chromatin remodelers influence genetic processes by altering nucleosome occupancy, positioning, and composition. In vitro, yeast ISWI and CHD remodelers require > 20 bp of extranucleosomal DNA for remodeling, but linker DNA in S. cerevisiae averages < 20 bp. To resolve this paradox, we have mapped t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-01 | E-GEOD-39430 | biostudies-arrayexpress
GenomicsDynamics of yeast ISWI and CHD chromatin remodeler genomic association (part 2)
Chromatin remodelers influence genetic processes by altering nucleosome occupancy, positioning, and composition. In vitro, yeast ISWI and CHD remodelers require > 20 bp of extranucleosomal DNA for remodeling, but linker DNA in S. cerevisiae averages < 20 bp. To resolve this paradox, we have mapped t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-01 | E-GEOD-39431 | biostudies-arrayexpress
ProteomicsPull-down affinity purifications using di-nucleosomes decorated with enhancer-associated modifications and incorporating 200bp linker DNA
Characteristic features of chromatin states are not limited to particular epigenetic modifications but include other regulatory cues, such as linker DNA length, typically ranging from around 35-55 bp in most eu- and heterochromatin domains (Valouev et al, 2011; Voong et al., 2016, Cell) to over 200 ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-12 | PXD041443 | Pride
Ndrs H3k4me1 H3k27ac Pull-down 
GenomicsNucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast
In Schizosaccharomyces pombe, DNA replication origins (ORIs) and meiotic recombination hotspots lack consensus sequences and show a bias towards mapping at large intergenic regions (IGRs). To explore whether this preference depended on underlying chromatin features, we have generated genome-wide nuc...
ORGANISM(S): Schizosaccharomyces pombe 
2011-12-31 | GSE28879 | GEO
GenomicsATAC-seq and MNase-seq Detect Distinct Modes of Chromatin Accessibility [Mnase]
Chromatin accessibility shapes the ability of transcription factors (TFs) and the transcriptional machinery to engage genomic DNA and therefore plays a central role in gene regulation. Two widely used approaches for profiling chromatin accessibility are micrococcal nuclease (MNase)-seq and assay for...
ORGANISM(S): Saccharomyces cerevisiae 
2026-09-08 | GSE346150 | GEO
GenomicsATAC-seq and MNase-seq Detect Distinct Modes of Chromatin Accessibility [ATAC-seq]
Chromatin accessibility shapes the ability of transcription factors (TFs) and the transcriptional machinery to engage genomic DNA and therefore plays a central role in gene regulation. Two widely used approaches for profiling chromatin accessibility are micrococcal nuclease (MNase)-seq and assay for...
ORGANISM(S): Saccharomyces cerevisiae 
2026-09-08 | GSE346229 | GEO
ProteomicsDissecting the effect of a long linker DNA on protein binding to di-nucleosomes decorated with promoter-associated PTMs
Characteristic features of chromatin states are not limited to particular epigenetic modifications but include other regulatory cues, such as linker DNA length, typically ranging from around 35-55 bp in most eu- and heterochromatin domains (Valouev et al, 2011; Voong et al., 2016, Cell) to over 200 ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD041835 | Pride
Ndrs Sv40 promoter H3k4me3 Pull-down H4ac H3ac 
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