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ProteomicsRegional differences in the small intestinal proteome of control mice and of mice lacking lysosomal acid lipase
Background: Despite recent studies investigating the involvement of single cells in regional differences of the small intestine (SI), the metabolic contribution of the duodenum, jejunum, and ileum to the overall intestinal metabolism is still unclear. Basic procedures and main findings: Using an unt...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-20 | PXD048378 | Pride
Metabolism Proteomics Lal Small intestine Macrophages 
ProteomicsOptic Atrophy 1 (OPA1) overexpression promotes dyslipidemia and atherosclerosis coupled to altered aortic VSMC function in LDL-R deficient mice
OPA1 (Optic Atrophy 1), a mitochondrial inner membrane protein involved in mitochondrial cellular metabolism, energy production, calcium homeostasis, and sterol and bile acids (BAs) synthesis. Mitochondria are plastic organelles continuously undergoing biogenesis, fusion, fission, and mitophagy. On ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD060450 | Pride
Mouse Proteomics 
ProteomicsDeletion of matrix metalloproteinase-12 improves energy metabolism and brown adipose tissue function in mice prone to develop cardiometabolic disease
Matrix metalloproteinase-12 (MMP12) is a proinflammatory protein secreted by macrophages. We have previously demonstrated that the genetic deletion of MMP12 in a cardiometabolic mouse model (low-density lipoprotein receptor-deficient (LdlrKO) mice fed a high-fat, sucrose- and cholesterol-enriched di...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-19 | PXD063623 | Pride
Cold exposure Untargeted proteomics Bat Mitochondrial processes Ldlr-deficient mice Mmp12 
ProteomicsIdentification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model
oActivationf brown adipose tissue (BAT) has gained central attention due to its known ability to dissipate energy and counteract cardiometabolic diseases (CMDs). The cold exposure on BAT activation and the induction of thermogenesis have been extensively studied, but reports on the effects at the pr...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-16 | PXD051640 | Pride
Cold exposure  brown adipose tissue  liver  untargeted proteomics  regulatory networks  tissue crosstalk 
ProteomicsASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.
Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of-function variants of ASGR1 are associated with a favorable metabolic profile and reduced incidence ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD046809 | Pride
Adipose tissue Liver Asgr1 Shotgun proteomics 
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