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ProteomicsCross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila
The intracellular bacterial pathogen Legionella pneumophila (L.p.) manipulates eukaryotic host ubiquitination machinery to form its replicative vacuole. While nearly 10% of L.p.’s ∼330 secreted effector proteins are ubiquitin ligases or deubiquitinases, a comprehensive measure of temporally resolved...
ORGANISM(S): Homo sapiens (Human) 
2024-01-23 | PXD019217 | Pride
Legionella 
ProteomicsEpigenetic reprogramming shapes the cellular landscape of schwannoma
Cell state evolution underlies tumor development and response to therapy1, but mechanisms specifying cancer cell states and intratumor heterogeneity are incompletely understood. Schwannomas are the most common tumors of the peripheral nervous system and are treated with surgery and ionizing radiatio...
ORGANISM(S): Homo sapiens (Human) 
2023-04-18 | PXD014798 | Pride
Human Cancer Lumos Maxquant 
ProteomicsData-independent acquisition protease-multiplexing enables increased proteome sequence coverage across multiple fragmentation modes
The use of multiple proteases has been shown to increase protein sequence coverage in proteomics experiments, but due to the additional sample preparation and analysis time required, it has not been widely adapted in routine proteomic workflows. While data-independent acquisition (DIA) has been prim...
ORGANISM(S): Homo sapiens (Human) 
2022-03-18 | PXD027242 | Pride
Dia Gluc Multiplexing Aspn 
ProteomicsFunctional diversification of the cephalopod proteome by RNA-editing
Coleoid cephalopods exhibit the highest levels of ADAR-mediated RNA editing in coding sequences of any known animal, yet the functional consequences of most recoding events remain largely unknown. Here we integrate proteomics with biochemical and cellular assays to characterize thousands of recoding...
ORGANISM(S): Homo sapiens (Human) Doryteuthis pealeii 
2026-10-09 | PXD078742 | Pride
Thermal proteome profiling Insoluble Stability shift Human Coleoid Phosphorylation Phosphoproteomics Cephalopod Aggregation 
ProteomicsA ciliopathy complex restrains centriolar length and builds distal appendages to initiate ciliogenesis.
Mitosis segregates into each daughter cell two centrioles, the older of which is uniquely capable of generating a cilium. How this older centriole, called the mother centriole, initiates ciliogenesis remains poorly understood. We have identified an evolutionarily conserved complex comprised of CEP90...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD022372 | Pride
Human Apms Gfp 
ProteomicsEGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma
Co-amplification of EGFR and EGFRvIII, a tumor-specific truncation mutant of EGFR, represent hallmark genetic lesions in glioblastoma. We report that EGFR and EGFRvIII stimulate the innate immune defense receptor Toll-like Receptor 2 (TLR2); and that knockdown of TLR2 led to a dramatic survival adva...
ORGANISM(S): Homo sapiens (Human) 
2024-11-26 | PXD034586 | Pride
Cancer Glioblastoma Lfq Phosphorylation 
ProteomicsATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism
Macroautophagy/autophagy is a catabolic process that targets a wide variety of cellular components including proteins, lipids, damaged organelles, and pathogens. The autophagy protein ATG7 is involved in autophagy initiation by facilitating the lipidation of LC3/GABARAPs at the growing autophagosoma...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-04-15 | PXD040548 | Pride
Apms 
ProteomicsPlasma proteomics of Ghanian children from high malaria transmission (HMT) and low malaria transmission (LMT) zones
We performed a longitudinal study of the plasma proteome of children infected with malaria and residing in low or high malaria transmission areas in Ghana. A mass spectrometry-based approach was used to identify putative protein-based biomarkers and predictors of resistance to malaria. Our findings ...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2025-02-11 | PXD060218 | Pride
Plasma Malaria Children Blood 
ProteomicsChlamydia trachomatis effector Dre1 interacts with dynactin to reposition host organelles during infection.
Chlamydia trachomatis is an obligate intracellular pathogen that replicates within a specialized membrane-bound compartment, the inclusion. Chlamydia species express a unique class of effectors, Incs, which are translocated from the bacteria by a Type III secretion system and are inserted into the i...
ORGANISM(S): Chlamydia trachomatis Chlamydia trachomatis Homo sapiens (Human) 
2025-03-31 | PXD028543 | Pride
Chlamydia Human Protein-protein interaction 
ProteomicsTau interactome mapping reveals dynamic processes associated with neurodegenerative diseases
The Tau (MAPT) protein drives neuronal dysfunction and toxicity in the brain in Alzheimer’s disease (AD) and other Tauopathies. To dissect the complexity of the Tau interactome that underlies this process we used two proteomic approaches to characterize the dynamic and multifaceted nature of Tau pro...
ORGANISM(S): Homo sapiens (Human) 
2022-01-11 | PXD026306 | Pride
Apex Ppi Tau 
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