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MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
MetabolomicsDIAMetAlyzer allows automated false-discovery rate-controlled analysis for data-independent acquisition in metabolomics
The extraction of meaningful biological knowledge from high-throughput mass spectrometry data relies on limiting false discoveries to a manageable amount. For targeted approaches in metabolomics a main challenge is the detection of false positive metabolic features in the low signal-to-noise ranges ...
2022-09-05 | MTBLS1108 | MetaboLights
ProteomicsProteomic profiling of NCI60 cell lines from Cancer Cell Line Encyclopedia
This ArrayExpress record contains meta-data and results of quantitative analysis of cell lines from the NCI-60 panel using pressure cycling technology (PCT) and SWATH-mass spectrometry. Each cell line was analyzed in duplicate. Raw data files are available at the EMBL-EBI protemics data archive (PRI...
ORGANISM(S): Homo sapiens 
2017-01-27 | E-PROT-2 | biostudies-arrayexpress
ProteomicsAssessing Technical and Biological Variation in SWATH-MS -based Proteomics: A case study in Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is renowned for its variable clinical course and response to therapy, suggesting a role for precision medicine. However, the molecular basis of CLL variability remains incompletely understood. Recent developments in data independent acquisition (DIA) -MS technolog...
ORGANISM(S): Homo sapiens (Human) 
2021-02-08 | PXD011330 | Pride
Cll Swath Leukaemia 
ProteomicsAnalysis of heat-shock treated Drosophila melanogaster embryos by SWATH-MS
Protein expression levels of Drosophila melanogaster embryos were monitored by SWATH-MS after heat-shock treatments.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-12-23 | PXD004753 | Pride
Embryo Swath Drosophila melanogaster 
ProteomicsSWATH mass spectrometry performance using extended ion assay libraries
The use of data-independent acquisition methods such as SWATH for mass spectrometry based proteomics is usually performed using peptide MS/MS reference ion assay libraries which enable identification and quantitation of peptide peak areas. Reference assay libraries can be generated locally through ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2016-05-12 | PXD002836 | Pride
Extended library Dia Swath 
ProteomicsSWATH-MS based characterization for proteome profile data of chemicals
Profile data analysis is useful to reveal the mode of action of low molecular weight compounds. Although transcriptome data have been the main target of the profile data analysis, it is unknown whether omics data in different layers could deserve the profile data analysis. In the first place, what i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-22 | PXD032785 | Pride
Mcf7 Olsa New mode of action Swath-ms 
ProteomicsComparison of fractionation proteomics for local SWATH library building
For data-independent acquisition by means of sequential window acquisition of all theoretical fragment ion spectra (SWATH), a reference library of data-dependent acquisition (DDA) runs is typically used to correlate the quantitative data from the fragment ion spectra with peptide identifications. Th...
ORGANISM(S): Homo sapiens (Human) 
2017-07-04 | PXD006190 | Pride
Library building Comparative study Swath-ms Fractionation proteomics Hesc 
ProteomicsSWATH-MS identification of CXCL7, LBP, TGFβ1 and PDGFRβ as novel biomarkers in human systemic mastocytosis.
We carried out a novel clinical biomarker investigation of the blood of systemic mastocytosis patients versus healthy controls; utilizing a new and emerging technology platform Sequential Window Acquisition of all Theoretical fragment-ion spectra mass spectrometry (SWATH-MS). This is the first use ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030947 | Pride
Mastocytosis Swath-ms Biomarkers 
MetabolomicsGNPS - A Novel Approach of SWATH- based metabolomics analysis using HMDB spectral library
Metabolomics is recognized as a potential approach to paving new avenues for clinical diagnosis, molecular medicine, and therapeutic drug monitoring and development. The conventional metabolomics analysis pipeline depends on the IDA technique. Although powerful, it still suffers from stochastic, not...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090242 | GNPS
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