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ProteomicsYeast SWI/SNF complex - Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex
This project uses crosslinked based mass spectrometry (CXMS) to study the architecture of yeast SWI/SNF complex.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-06-14 | PXD005948 | Pride
Swi/snf bs3 crosslinking architecture 
ProteomicsDrosophila BAF complex crosslinking (
Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes are large, multisubunit molecular machines that play vital roles in regulating genomic architecture and are frequently disrupted in human cancer and developmental disorders. To date, the organization and pathway of assembly of...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-10-18 | PXD010123 | Pride
Swi/snf Baf Cxms Bs3 Architecture 
ProteomicsHuman BAF complex (HA-DPF2 pulldown and SS18-Flag pulldown)
Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes are large, multisubunit molecular machines that play vital roles in regulating genomic architecture and are frequently disrupted in human cancer and developmental disorders.Using affinity purification of endogenous complexes f...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD010124 | Pride
Bs3 crosslinking Baf complex Hswi/snf 
ProteomicsArchitecture of the chromatin remodeler RSC and insights into its nucleosome engagement
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin remodeler family, plays critical roles in geno...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-27 | PXD019400 | Pride
Yrsc cxms cryo-em 
ProteomicsA structural model of the human mSWI/SNF (BAF) complex bound to the nucleosome informs disease mechanisms
Mammalian SWI/SNF complexes are multi-component ATP-dependent chromatin-remodeling complexes that regulate genomic architecture. Here we present the first structural model of the human canonical BAF chromatin-remodeling complex bound to a nucleosome generated using cryo-EM, cross-linking mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD020992 | Pride
Homology model Cryo-em Atp-dependent chromatin remodeling Nucleosome acidic patch Yeast swi/snf Mammalian swi/snf Canonical baf complex Human disease Mutations 
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