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TranscriptomicsExpression in arp6 and swr1 deletion mutants
Actin-related proteins are ubiquitous components of chromatin remodelers, and are conserved from yeast to man. We have examined the role of the budding yeast actin-related protein Arp6 in gene expression, both as a component of the SWR1 complex (SWR-C) and in its absence. We mapped Arp6-binding site...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-01 | E-GEOD-17780 | biostudies-arrayexpress
TranscriptomicsIn the absence of H2A.Z, the SWR1 histone replacement complex causes genetic instability, stress and genome transcription misregulation
The SWR1 complex replaces the canonical histone H2A with the variant H2A.Z (Htz1 in yeast) at specific chromatin regions. This dynamic alteration in nucleosome structure provides a molecular mechanism to regulate transcription. Here we analysed the transcription profiles of single and double mutants...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-18 | E-GEOD-21571 | biostudies-arrayexpress
TranscriptomicsRegulation of microRNA-mediated developmental changes by the SWR1 chromatin remodeling complex in Arabidopsis thaliana
We investigated small-RNA populations from Arabidopsis thaliana Col-0 between Wild-type and the arp6 mutant with focus on micro-RNA levels. Small-RNA sequencing was performed for 4 bioreps (with 4 technical replicates each) of each condition. Size selection was done by manually cutting bands.
ORGANISM(S): Arabidopsis thaliana 
2016-05-31 | E-MTAB-4498 | biostudies-arrayexpress
TranscriptomicsNucleosome free DNA- and acetyl histone-binding components recruit SWR1 to yeast promoters for H2A.Z replacement
The histone variant H2A.Z is a genome-wide signature of nucleosomes proximal to eukaryotic regulatory DNA. While the multi-subunit SWR1 chromatin remodeling complex is known to catalyze ATP-dependent deposition of H2A.Z, the mechanism of recruitment to S. cerevisiae promoters has been unclear. A sen...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-16 | E-GEOD-49183 | biostudies-arrayexpress
ProteomicsDrosophila SWR1 and NuA4 complexes are defined by DOMINO isoform
Histone acetylation and deposition of H2A.Z variant are integral aspects of active transcrip-tion. In Drosophila, the single DOMINO chromatin regulator complex is thought to combine both activities via an unknown mechanism. Here we show that alternative isoforms of the DOMINO nucleosome remodeling A...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-05-27 | PXD017729 | Pride
Nua4 Drosophila Domino H3ac Swr1 H4ac 
ProteomicsNuA4 and SWR1 complex in Plasmodium falciparum
In this study, we identified an MYST-associated complex in P. falciparum, which contains 11 of 13 conserved NuA4 subunits based on their domain structures. Meanwhile, reciprocal pulldowns not only confirmed the NuA4-like complex but also identified an SWR1-like complex, a histone remodeling complex,...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-03-18 | PXD046547 | Pride
Plasmodium Nua4 Dna repair Swr1 
TranscriptomicsStepwise histone replacement by SWR1 requires dual activation with histone H2A.Z and canonical nucleosome
Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes with H2A.Z in an ATP-dependent manner. Here, we show that promoter-proximal nucleosomes are hi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-10-12 | E-GEOD-24618 | biostudies-arrayexpress
GenomicsSWR1 and ERECTA in regulating female gametophyte
To study the mechanism by which SWR1 and ERECTA regulate female gametophyte.
PRJEB42278 | ENA
UnknownSWR1 complex poises heterochromatin boundaries for antisilencing activity propagation.
Not available
S-EPMC2863710 | biostudies-literature
UnknownMolecular architecture of the ATP-dependent chromatin-remodeling complex SWR1.
Not available
S-EPMC3776929 | biostudies-literature
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