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GenomicsATG-9-Mediated Synaptic Autophagy Promotes Aversive Learning under Stress in C. elegans
ATG-9-Mediated Synaptic Autophagy Promotes Aversive Learning under Stress in C. elegans
PRJNA1279070 | ENA
TranscriptomicsATG-9-Mediated Synaptic Autophagy Promotes Aversive Learning under Stress in C. elegans
Autophagy is a degradative process that maintains cellular homeostasis and functions. Autophagy biogenesis at neuronal synapses requires synaptic proteins, but its impact on synaptic functions is incompletely understood. Here we show that, in Caenorhabditis elegans, synaptic ATG-9, the only transmem...
ORGANISM(S): Caenorhabditis elegans 
2026-05-21 | GSE300122 | GEO
UnknownThe GTPase Rab26 links synaptic vesicles to the autophagy pathway.
Not available
S-EPMC4337689 | biostudies-literature
UnknownImbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.
Not available
S-EPMC8942553 | biostudies-literature
ProteomicsChaperone-mediated autophagy sex-specifically regulates neuronal activity by remodeling the synaptic proteome
Chaperone-mediated autophagy (CMA) declines in aging and neurodegenerative diseases. CMA loss in neurons leads to neurodegeneration and behavioral changes in mice, but the role of CMA in neuronal physiology is largely unknown. Here, we show that CMA deficiency causes neuronal hyperactivity, disrupte...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-04 | PXD057545 | Pride
Aging  alzheimer’s disease  autophagy  hyperexcitability  lysosomes  neurodegeneration  sexual dimorphism  synaptic plasticity 
UnknownLight-Activated ROS Production Induces Synaptic Autophagy.
Not available
S-EPMC6433757 | biostudies-literature
UnknownAutophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone <i>Hsc70-5</i> in <i>Drosophila</i>.
Not available
S-EPMC8526020 | biostudies-literature
UnknownNeuronal Autophagy in Synaptic Functions and Psychiatric Disorders.
Not available
S-EPMC6986983 | biostudies-literature
ProteomicsAutophagy is dispensable for the maintenance of parvalbumin interneurons but required for their inhibitory neurotransmission and memory
Previous studies have demonstrated the requirement of autophagy for neuronal survival and synaptic function, mostly focusing on projection neurons and excitatory neurotransmission. Here, we examine the effects of conditional atg5 ablation in neurons expressing parvalbumin (PV-cKO), which in the fore...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD035264 | Pride
Autophagy Mus musculus Neurons Fusion 
UnknownIdentification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling.
Not available
S-EPMC11032469 | biostudies-literature
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