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MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
GenomicsPumilio2 and Staufen2 selectively balance the synaptic proteome
Pumilio2 and Staufen2 selectively balance the synaptic proteome
PRJNA726236 | ENA
UnknownHidden proteome of synaptic vesicles in the mammalian brain.
Not available
S-EPMC7776996 | biostudies-literature
ProteomicsCortical layer 5 neuron-specific synaptic protein profiling suggests differential vulnerability to neurodevelopmental disorders
Pyramidal neurons in the cortex are embedded in distinct information processing pathways. Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons receive different input and project to distinct brain regions. The synaptic molecular signatures that define synaptic connectivity ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD046812 | Pride
Synaptic proteome Neurodevelopment Turboid 
ProteomicsCross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes
Synaptic vesicles are storage organelles for neurotransmitters in the pre-synaptic cytosol. When an action potential arrives at the pre-synaptic terminal, they fuse with the pre-synaptic membrane and neurotransmitters are released. In this project, we set out to study the protein interactions formed...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-12-09 | PXD020859 | Pride
Chemical cross-linking Mass spectrometry Protein networks Synaptic vesicles Synaptophysin Synaptobrevin-2 
ProteomicsSynaptic Proteome of the Trisynaptic Circuit
Electrophysiological features of excitatory synapses vary widely throughout the brain, granting neuronal circuits the ability to decode and store diverse patterns of information. Synapses formed by the same neurons have similar electrophysiological characteristics, belonging to the same type. Howeve...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-25 | PXD052913 | Pride
Synapse Trisynaptic circuit Hippocampus Synaptic type proteome Mouse 
ProteomicsDynamics of the mouse brain cortical synaptic proteome during postnatal brain development
Development of the brain involves the formation and maturation of numerous synapses. This process requires prominent changes of the synaptic proteome and potentially involves thousands of different proteins at every synapse. To date the proteome analysis of synapse development has been studied spars...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004129 | Pride
Mouse Development Postnatal Cortex 
ProteomicsHidden Proteome of Synaptic Vesicles in the Mammalian Brain
current synapse proteomics are restricted to “average” composition of abundant synaptic proteins. Here we performed a subcellular proteomic workflow that could identify and quantify the deep proteome of synaptic vesicles purified from rat whole brain, including previously missing proteins present in...
ORGANISM(S): Rattus Norvegicus Albus 
2020-12-31 | PXD021549 | JPOST Repository
TranscriptomicsPumilio2 and Staufen2 selectively balance the synaptic proteome
Cells, in particular neurons, have the capacity to adapt to environmental stimuli, a phenomenon termed cellular plasticity. The underlying processes are controlled by a network of RNA-binding proteins (RBPs). Their impact on cellular plasticity, however, is largely unknown. To address this important...
ORGANISM(S): Rattus norvegicus 
2021-04-30 | GSE173596 | GEO
ProteomicsProteomic analysis of brain region and gender-specific synaptic protein expression in the adult mouse brain
In a wide range of synaptopathies a sex/gender bias in prevalence and clinical course has been reported. Therefore, analysis of the synaptic proteinaceous inventory in different brain regions in males and females is very desirable in understanding the molecular basis of brain function and the etiolo...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD015610 | Pride
Sex/gender bias Prefrontal cortex Hippocampus Cerebellum Striatum Synaptic junction Label-free quantification Data-independent acquisition 
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