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MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
ProteomicsSmall intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning
Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our res...
ORGANISM(S): Mus Musculus 
2024-10-28 | PXD057241 |
ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
ProteomicsMicroglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
INPP5D, which encodes the lipid phosphatase SHIP1, is one of the most common genes associated with the risk of Alzheimer’s disease and is enriched in microglia in the central nervous system. SHIP1 has been found to be highly expressed in plaque-associated microglia. However, how it regulates microgl...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-04 | PXD052118 | Pride
Complement Ship1 Synaptic pruning Inpp5d Microglia 
GenomicsERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [RNA]
ERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [RNA]
PRJNA1149734 | ENA
GenomicsERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [ChIP-seq]
ERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [ChIP-seq]
PRJNA1149674 | ENA
GenomicsMicroglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
Microglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
PRJNA1116096 | ENA
GenomicsMicroglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
Microglial SHIP1 controls synaptic pruning in the developing hippocampus via the complement system
PRJNA1171307 | ENA
UnknownSynaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses.
Not available
S-EPMC12478112 | biostudies-literature
TranscriptomicsProgranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Microglia repair injury and maintain homeostasis in the brain, but whether aberrant microglial activation can contribute to neurodegeneration remains unclear. Here, we use transcriptome profiling to demonstrate that deficiency in frontotemporal dementia (FTD) gene progranulin (Grn) leads to an age-d...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-75083 | biostudies-arrayexpress
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