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TranscriptomicsTranscription profiling of human Alzheimers disease patients to identify genes regulating synaptic function and neuroplasticity in incipient AD
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification which are likely induced by toxic beta-amyloid oligomers (dAbeta). To identify molecular targets downstream of dAbeta binding we prepared synaptoneurosomes from frontal cortex of control a...
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12685 | biostudies-arrayexpress
TranscriptomicsFiber and NMJ / synaptic gene expression comparisons in rat extraocular muscle (EOM) and tibialis anterior (TA) muscle.
Purpose: To examine and characterize the expression profile of genes expressed at the neuromuscular junctions (NMJs) of extraocular muscles (EOMs) in comparison to the NMJs of tibialis anterior muscle (TA). Methods: Adult rat rectus EOMs and TAs were dissected, flash-frozen, serially sectioned and ...
ORGANISM(S): Rattus norvegicus 
2010-04-28 | E-GEOD-15737 | biostudies-arrayexpress
TranscriptomicsCircadian and Sleep regulation of synaptic RNA
Circadian rhythms are present across almost all species and affect several physiological and behavioral aspects of living organisms. The evolutionary advantage conferred by these rhythms could be their anticipatory properties. In the nervous system, anticipation is particularly interesting due to th...
ORGANISM(S): Mus musculus 
2019-02-28 | E-MTAB-7347 | biostudies-arrayexpress
ProteomicsProteomics profiling of Neuronal Mitochondria
Mitochondria are the ‘power-houses’ of all cells, generating ATP to fuel numerous pathways which are vital for cellular form and function (1). Neuronal processes and synapses present a constant demand for ATP to maintain ionic gradients and neurotransmission events (2), promoting sub-populations of ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005537 | Pride
Neuron Proteomics Mitochondria Synapse Neurodegeneration 
GenomicsCircadian and Sleep regulation of synaptic RNA
Circadian and Sleep regulation of synaptic RNA
PRJEB31165 | ENA
ProteomicsMicroRNA137-loaded lipid nanoparticles regulate synaptic proteins in the prefrontal cortex
Genome-wide association studies indicate allele variants in MIR137, the host gene of microRNA-137 (miR137), confer an increased risk of schizophrenia (SCZ). Expression of miR137 and its targets, many of which regulate synaptic functioning, are also associated with an increased risk of SCZ. As a resu...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-05 | PXD041648 | Pride
Schizophrenia Isobaric labeling Prefrontal cortex Mass spectrometry Lipid nanoparticle Personalized medicine Microrna Quantitative proteomics Synaptic proteins 
GenomicsThe Habenular G-Protein-Coupled Receptor 151 regulates synaptic plasticity and nicotine intake
The Habenular G-Protein-Coupled Receptor 151 regulates synaptic plasticity and nicotine intake
PRJNA601907 | ENA
UnknownEnergy efficient synaptic plasticity.
Not available
S-EPMC7082127 | biostudies-literature
UnknownSynaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson's Disease.
Not available
S-EPMC8636601 | biostudies-literature
TranscriptomicsAlterations to the Synaptic Transcriptome in Response to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice
Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug use are caused, at least in part, by ethanol-ev...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-73018 | biostudies-arrayexpress
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