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Metabolomics1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their underlying etiologies are markedly different. We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF). SF was a...
2018-10-11 | MTBLS564 | MetaboLights
Metabolomics1H-NMR-Based Analysis for Exploring Knee Synovial Fluid Metabolite Changes after Local Cryotherapy in Knee Arthritis Patients
Rehabilitation using cryotherapy has widely been used in inflammatory diseases to relieve pain and decrease the disease activity. The aim of this study was to explore the metabolite changes in inflammatory knee-joint synovial fluids following local cryotherapy treatment (ice or cold CO2). We used pr...
2020-11-10 | MTBLS1894 | MetaboLights
TranscriptomicsSingle cell RNA and CITE sequencing of cells from synovial tissue biopsies of healthy donors, and Rheumatoid Arthritis (RA) patients with active disease or sustained clinical remission
The dataset includes the raw FASTQ files generated from the 10x Genomics Single Cell 3’ v3.1 experiments. For samples processed with TotalSeq Hashtag reagents, the corresponding hashtag oligonucleotide and condition annotations are provided as separate .csv files. The processed matrices contain filt...
ORGANISM(S): Homo sapiens 
2024-12-06 | E-MTAB-14213 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of the human synovium in inflammatory arthritis
The study presents: - an optimized synovium dissociation protocol for single cell RNA-sequencing studies of the human synovium. The protocol enables the isolation of high yield of viable synovial cells from prospectively collected fresh synovial biopsies from patients with inflammatory arthritis wi...
ORGANISM(S): Homo sapiens 
2024-04-21 | E-MTAB-11791 | biostudies-arrayexpress
TranscriptomicsSynovial Gene Signatures Associated with the Development of Rheumatoid Arthritis in At Risk Individuals
Transcriptional profiling of human synovial tissue from thirteen individuals with arthralgia who were IgM rheumatoid factor (RF) and/or anti-citrullinated protein antibody (ACPA) positive and without any evidence of arthritis. Survival analysis was used to identify transcripts associated with arthri...
ORGANISM(S): Homo sapiens 
2022-09-01 | E-MTAB-11874 | biostudies-arrayexpress
TranscriptomicsThe relationship between the gene expression profile in the synovium of RA patients at baseline and the clinical response to infliximab treatment
Background: Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-21537 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq of ankylosing spondylitis lymphocytes from peripheral blood and synovial fluid
Single-cell transcriptome of >55,000 cells multiplexed into 4 channels obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis,.
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-10948 | biostudies-arrayexpress
TranscriptomicsModulation of the TNF-induced macrophage response by synovial fibroblasts
Here we explored how the human macrophage response to tumor necrosis factor (TNF) is regulated by human synovial fibroblasts, the representative stromal cell type in the synovial lining of joints that become activated during inflammatory arthritis. Genome-wide transcriptome analysis (RNAseq) showed ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-57723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Experiment Overall Design: Synovial tissue was obtained from open joint replacement surgery or Experiment Overall Design: arthroscopic synovectomy. Patients with RA or OA (n = 6 each...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-7669 | biostudies-arrayexpress
TranscriptomicsThe role of distinct synovial tissue macrophage populations in shaping synovial tissue microenvironment
We tested the role of distinct STM populations in the modulation of synovial tissue environment in ex vivo STM-FLS micro co-cultures. We first FACS-sorted total synovial tissue fibroblasts as we described previously from biopsies of RA patients. FLS were seeded at 3000/well alone or in contact with ...
ORGANISM(S): Homo sapiens 
2020-04-18 | E-MTAB-8873 | biostudies-arrayexpress
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