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ProteomicsSyntaxin-3 is a Weibel-Palade body localized SNARE protein that regulates Von Willebrand factor secretion from endothelial cells
Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously identified STXBP1 as the link between the Rab27A-Slp4-a ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD006176 | Pride
Endothelial cells Proteomics Weibel-palade body Snare machinery Syntaxin-3 Von willebrand factor 
ProteomicsInteraction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells
The endothelium stores the hemostatic protein Von Willebrand factor (VWF) in endothelial storage organelles called Weibel-Palade bodies (WPBs). During maturation, WPBs recruit a complex of Rab GTPases and effectors that associate with components of the SNARE machinery that control WPB exocytosis. Re...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD012809 | Pride
Weibel-palade body  snare protein  syntaxin  protein-protein interactions 
UnknownApical targeting of syntaxin 3 is essential for epithelial cell polarity.
Not available
S-EPMC2063918 | biostudies-literature
UnknownThe SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons.
Not available
S-EPMC5035089 | biostudies-literature
UnknownSyntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons.
Not available
S-EPMC6971263 | biostudies-literature
UnknownSoluble syntaxin 3 functions as a transcriptional regulator.
Not available
S-EPMC5900775 | biostudies-literature
UnknownThe Habc domain of syntaxin 3 is a ubiquitin binding domain.
Not available
S-EPMC7721868 | biostudies-literature
UnknownRab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes.
Not available
S-EPMC4518445 | biostudies-literature
UnknownSyntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival.
Not available
S-EPMC7456102 | biostudies-literature
UnknownMunc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.
Not available
S-EPMC3905451 | biostudies-literature
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