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TranscriptomicsTranscription profiling of mouse day 5 5cc7 T cell blasts
Our aim was to get a general sense of which proteins are expressed in 5cc7 T cell blasts. We use these cells for a number of different experiments in our lab Experiment Overall Design: RNA was isolated from day 5 5cc7 T cell blasts. This RNA was converted to cRNA and used to hybridize 2 affymetrix...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4050 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human JAK1 wild-type and JAK1 mutation-positive T cell acute lymphoblastic leukemia blasts
Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and diff...
ORGANISM(S): Homo sapiens 
2009-10-02 | E-GEOD-18239 | biostudies-arrayexpress
ProteomicsCanagliflozin synergises with serine synthesis pathway inhibition mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature associated with NOTCH1 mutations is heightened oxidative metabolism enabling the exponential proliferation of T-ALL blasts. As such, targeting mitochondri...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD069587 | Pride
Lc-msms T-all Cell line 
TranscriptomicsTranscription profiling of human T cells from patients presenting with AML compared with healthy T cells
Work previously published by our group has demonstrated that T cells from patients with chronic lymphocytic leukaemia (CLL) show differentially regulated genes compared with healthy T cells. This study was initiated to examine if these gene expression changes were unique to CLL T cells or common to ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-14924 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-ALL (COG study 9404)
The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure. Based on the hypothesis that microarrays might identify patients who fail therapy, we used the Affymetrix U133 Plus 2.0 chip and prediction analysis of mic...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-14615 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-ALL patients (COG study 8704)
The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure. Based on the hypothesis that microarrays might identify patients who fail therapy, we used the Affymetrix U133 Plus 2.0 chip and prediction analysis of mic...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-14613 | biostudies-arrayexpress
TranscriptomicsmiR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia
MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoiesis to express miRNA-126 across all differentiation stages. Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible mi...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-78078 | biostudies-arrayexpress
ProteomicsHuman γδ T-cell, LC-MS/MS - Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor
A new method of graft manipulation based on physical removal of αβ+ T cells and CD19+ B cells, leaving mature NK cells and γδ T cells in the graft, has been recently developed for HLA-haploidentical HSCT. We demonstrated that γδ T cells collected from transplanted patients are endowed with capacity ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002629 | Pride
Human Γδ t-cell Leukemia cells Zolendric acid (zol) 
GenomicsRNASeq analysis for T-cell blasts from individuals with an AIOLOS Q402* mutation and healthy controls
RNASeq analysis for T-cell blasts from individuals with an AIOLOS Q402* mutation and healthy controls
PRJNA853777 | ENA
TranscriptomicsTranscription profiling of human newly diagnosed T-ALL patients treated in the Childrens Oncology Group (COG) T-ALL Study 9404
The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure. Based on the hypothesis that microarrays might identify patients who fail therapy, we used the Affymetrix U133 Plus 2.0 chip and prediction analysis of mic...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-14618 | biostudies-arrayexpress
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