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TranscriptomicsAzathioprine Pharmacogenomics in Myasthenia Gravis Patients
Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction, whose clinical hallmark is muscle weakness and early fatigability. Azathioprine (AZA) is commonly used in Myasthenia Gravis therapy. AZA is a purine antagonist, which inhibits the cell cycle in the resting and DNA ...
ORGANISM(S): Homo sapiens 
2016-05-01 | E-MTAB-4489 | biostudies-arrayexpress
GenomicsH3K36ac is an evolutionary conserved histone modification that marks active genes in plants
In eukaryotic cells, DNA is tightly packed in the nucleus in chromatin which has histones as its main protein component. Histones are subject to a large number of distinct post-translational modifications, whose sequential or combinatorial action affects genome function. Here, we report the identifi...
ORGANISM(S): Arabidopsis thaliana 
2016-04-05 | E-GEOD-74841 | biostudies-arrayexpress
TranscriptomicsDifferential regulation of SBF and MBF target genes by genotoxic stress occurs via Rad53-dependent inactivation of the MBF correpressor Nrm1
MBF and SBF transcription factors regulate a large family of coordinately expressed G1/S genes required for early cell cycle functions including DNA replication and repair. SBF is inactivated upon S phase entry by Clb/CDK whereas MBF targets are repressed by the corepressor, Nrm1. Using genome-wide ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-15 | E-GEOD-33695 | biostudies-arrayexpress
GenomicsThe Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis. [ChIP_seq]
Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and S...
ORGANISM(S): Mus musculus 
2012-04-09 | E-GEOD-30972 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in acaricide exposed Rhipicephalus (Boophilus) microplus.
A R. microplus microarray was used to study differential gene expression in acaricide exposed larvae from an amitraz-resistant strain. The acaricide treatments were: organophosphate (OP), pyrethroid, ivermectin, and amitraz. The microarrays contained over 13,000 probes corresponding to each member...
ORGANISM(S): Rhipicephalus microplus 
2010-05-14 | E-GEOD-10171 | biostudies-arrayexpress
GenomicsChIP-Seq of RNA polymerase and co-factors in Jurkat T-ALL cells
Transcription of oncogenes is regulated by co-factors, some of which are now targetable with small molecules. This series contains ChIP-Seq targeting transcriptional co-factors and RNA polymerase from cells treated with small molecules targeting co-factors. ChIP-Seq of RNA polymerase and co-factors...
ORGANISM(S): Homo sapiens 
2016-06-27 | E-GEOD-83777 | biostudies-arrayexpress
TranscriptomicsRegulation of Transcription Termination by Glucosylated Hydroxymethyluracil, Base J, in L. major and T. brucei
Base J, β-D-glucosyl-hydroxymethyluracil, is an epigenetic modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. J is enriched at sites involved in RNA Polymerase (RNAP) II initiation and termination. We have previously demonstrated a role of J in regulating...
ORGANISM(S): Trypanosoma brucei 
2015-05-18 | E-GEOD-57621 | biostudies-arrayexpress
UnknownTranscriptome Profiling to Identify Genes Involved in Mesosulfuron-Methyl Resistance in Alopecurus aequalis.
Not available
S-EPMC5552757 | biostudies-literature
TranscriptomicsDifferentially Expressed Genes between Drought-tolerant and Drought-sensitive Barley Genotypes
Drought tolerance is a key trait for increasing and stabilizing barley productivity in dry areas worldwide. Identification of the genes responsible for drought tolerance in barley (Hordeum vulgare L.) will facilitate understanding of the molecular mechanisms of drought tolerance, and also genetic im...
ORGANISM(S): Hordeum vulgare 
2009-05-13 | E-GEOD-15970 | biostudies-arrayexpress
TranscriptomicsEnzymatic methyl-seq of embryonic development in the fat-tailed dunnart (Sminthopsis crassicaudata)
DNA methylation (5mC) is an epigenetic mark that plays a critical role in defining cell fate. Following fertilisation, DNA methylation inherited from gametes must be reprogrammed to establish totipotency and enable the parental-to-zygotic transition. To accomplish this, non-mammalian vertebrates suc...
ORGANISM(S): Sminthopsis crassicaudata 
2025-11-14 | E-MTAB-16076 | biostudies-arrayexpress
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