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ProteomicsAllosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism
BCL-xL promotes cell survival by binding BH3-only initiators through its hydrophobic groove. Combining resonance energy transfer assays and molecular dynamics simulations, we unravel that membrane anchoring of BCL-xL via its C-terminal tail selectively advantages binding to membrane-anchored PUMA in...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066303 | Pride
Puma Tail anchors Bcl-xl Bax Tripletof 5600+ Bh3 mimetic Swath 
TranscriptomicsCircular RNAs are a large class of animal RNAs with regulatory potency (RNA-Seq)
Circular RNAs (circRNAs) in animals are an enigmatic class of RNAs with unknown function. To systematically explore circRNAs, we sequenced and computationally analyzed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, with oftentimes tissue/developmental stage ...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-43572 | biostudies-arrayexpress
UnknownAllosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism.
Not available
S-EPMC12660782 | biostudies-literature
UnknownHydrophobic profiles of the tail anchors in SLMAP dictate subcellular targeting.
Not available
S-EPMC2712456 | biostudies-literature
UnknownDivergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors.
Not available
S-EPMC548020 | biostudies-literature
UnknownBacterial tail anchors can target to the mitochondrial outer membrane.
Not available
S-EPMC5525287 | biostudies-literature
UnknownA novel sortase, SrtC2, from Streptococcus pyogenes anchors a surface protein containing a QVPTGV motif to the cell wall.
Not available
S-EPMC516832 | biostudies-literature
UnknownStructure of the intact tail machine of Anabaena myophage A-1(L).
Not available
S-EPMC10966104 | biostudies-literature
UnknownRibosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.
Not available
S-EPMC7862611 | biostudies-literature
TranscriptomicsCircular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using t...
ORGANISM(S): Homo sapiens 
2015-04-24 | E-GEOD-65926 | biostudies-arrayexpress
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